Doxycycline Monohydrate
Brand names: Doxycycline Ir-Dr, Doxycycline Monohydrate, Oracea
Part of: Common antibiotics
At a glance
- Medicare prescriptions, 2024
- 1,285,524
- Medicare drug cost
- $23.4M
- Average cost per prescription
- $18.23
- Clinicians who prescribed it
- 45,144
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline capsules, USP and other antibacterial drugs, doxycycline capsules, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Doxycycline capsules, USP are indicated for the treatment of the following infections: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae. Respiratory tract infections caused by Mycoplasma pneumoniae. Lymphogranuloma venereum caused by Chlamydia trachomatis. Psittacosis (ornithosis) caused by Chlamydophila psittaci. Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence. Inclusion conjunctivitis caused by Chlamydia trachomatis. Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis. Nongonococcal urethritis caused by Ureaplasma urealyticum. Relapsing fever due to Borrelia recurrentis.
From the FDA-approved prescribing information (label dated March 2026). Full labels on DailyMed (opens in a new tab)
Who prescribes it
- Nurse Practitioners 20.6%
- Family Medicine 19.5%
- Physician Assistants 15.0%
- Internal Medicine 12.6%
- Dermatology 10.5%
- Emergency Medicine 3.8%
- Ophthalmology 2.6%
- Podiatrists 1.9%
- Mohs Surgery 1.8%
- Infectious Disease 1.7%
- Pulmonology 1.3%
- Optometrists 1.2%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions rose 36% from 2019 to 2024.
Biggest change by state since 2019
- Massachusetts +111%
- Connecticut +77%
- Nebraska +67%
- Maryland +67%
- New Hampshire +63%
- Colorado (smallest change) −15%
- New Mexico (smallest change) +1%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
What it looks like
Pills from 5 makers on file. The same medicine can look different depending on who made it, so check the imprint (the letters and numbers on the pill) with your pharmacist if a refill looks different.
Advanced Rx Pharmacy of Tennessee, LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 100 mg | yellow round tablet, 9 mm | 1123 |
Chartwell Rx, LLC.
| Strength | Looks like | Imprint |
|---|---|---|
| 50 mg | white capsule, 14 mm | CE410 50MG |
| 75 mg | white capsule, 18 mm | CE412 75MG |
| 100 mg | white capsule, 19 mm | CE411 100MG |
| 150 mg | brown capsule, 22 mm | CE413 150MG |
Direct Rx
| Strength | Looks like | Imprint |
|---|---|---|
| 100 mg | brown capsule, 19 mm | NL792 100MG |
| 100 mg | orange capsule, 19 mm | 707 |
Direct_rx
| Strength | Looks like | Imprint |
|---|---|---|
| 100 mg | blue capsule, 18 mm | RX616 |
Rpk Pharmaceuticals, Inc.
| Strength | Looks like | Imprint |
|---|---|---|
| 100 mg | white capsule, 19 mm | WATSON 411 100 MG |
Source: DailyMed (U.S. National Library of Medicine), from each maker’s FDA drug listing. A few makers are shown, not every one. Never take a pill you can’t identify; ask a pharmacist.
Industry payments about this drug
Drug makers reported $42 in payments to clinicians that named this drug in 2025 (meals, speaking, consulting and similar).
- Galderma Laboratories, L.P. $42
Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor
Recalls and shortages
Not on the FDA drug shortage list.
3 recalls since 2020
- Apr 2022 · McKesson Medical-Surgical Inc. Corporate Office · Class II
cGMP deviations: Temperature abuse - Jan 2022 · Cardinal Healthcare · Class II
CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions. - Mar 2020 · Sun Pharmaceutical Industries, Inc. · Class II
CGMP Deviations: Doxycycline capsules were not manufactured under Current Good Manufacturing Practice conditions.
Recalls usually affect specific lots from one maker, not every version of a drug. Class I is the most serious; most drug recalls are Class II. FDA recalls (opens in a new tab)
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.