Fluoxetine Hcl
Brand names: Fluoxetine Dr, Fluoxetine Hcl, Prozac
Part of: Antidepressants
At a glance
- Medicare prescriptions, 2024
- 6,698,198
- Medicare drug cost
- $76.2M
- Average cost per prescription
- $11.37
- Clinicians who prescribed it
- 165,072
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
Fluoxetine tablets are indicated for the treatment of: Major Depressive Disorder (MDD). The efficacy of fluoxetine tablets in MDD was established in one 5-week trial, three 6-week trials, and one maintenance study in adults. The efficacy of fluoxetine tablets was also established in two 8- to 9-week trials in pediatric patients 8 to 18 years of age. Obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD). The efficacy of fluoxetine tablets in OCD was demonstrated in two 13-week trials in adults and one 13-week trial in pediatric patients 7 to 17 years of age. Binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa. The efficacy of fluoxetine tablets in Bulimia Nervosa was demonstrated in two 8-week trials and one 16-week trial in adults. Panic Disorder, with or without agoraphobia. The efficacy of fluoxetine tablets in Panic Disorder was demonstrated in two 12-week trials in adults.
From the FDA-approved prescribing information (label dated December 2025). Full labels on DailyMed (opens in a new tab)
Boxed warning
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behavior. Advise families and caregivers of the need for close observation and communication with the prescriber. Fluoxetine is not approved for use in children less than 7 years of age. WARNING: SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing information for complete boxed warning. Increased risk of suicidal thinking and behavior in children, adolescents,…
The FDA’s strongest warning on a label. It doesn’t mean the drug is unsafe for most people; talk to your doctor or pharmacist before stopping or changing any medicine.
Who prescribes it
- Family Medicine 28.8%
- Internal Medicine 18.3%
- Nurse Practitioners 15.3%
- Psychiatry 14.8%
- Psychiatric Nurse Practitioners 11.3%
- Physician Assistants 6.0%
- Geriatric Medicine 1.0%
- General Practice 1.0%
- Child & Adolescent Psychiatry 0.9%
- Neurology 0.6%
- Hospitalist 0.3%
- Pediatrics 0.2%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions rose 9% from 2019 to 2024.
Biggest change by state since 2019
- Delaware +26%
- Nebraska +19%
- Louisiana +18%
- Montana +17%
- Florida +17%
- Puerto Rico (smallest change) −8%
- California (smallest change) −6%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
What it looks like
Pills from 5 makers on file. The same medicine can look different depending on who made it, so check the imprint (the letters and numbers on the pill) with your pharmacist if a refill looks different.
Direct_rx
| Strength | Looks like | Imprint |
|---|---|---|
| 20 mg | green capsule, 18 mm | SG 114 |
Direct_rx
| Strength | Looks like | Imprint |
|---|---|---|
| 40 mg | white capsule, 21 mm | SG 115 |
Directrx
| Strength | Looks like | Imprint |
|---|---|---|
| 40 mg | green capsule, 18 mm | RX632 |
Dista Products Company
| Strength | Looks like | Imprint |
|---|---|---|
| 10 mg | green capsule, 16 mm | DISTA 3104 PROZAC 10 MG |
| 20 mg | green capsule, 16 mm | DISTA 3105 PROZAC 20 MG |
| 40 mg | green capsule, 18 mm | DISTA 3107 PROZAC 40 MG |
Strides Pharma Science Limited
| Strength | Looks like | Imprint |
|---|---|---|
| 60 mg | white capsule, 14 mm, scored to split in 2 | F 60 |
Source: DailyMed (U.S. National Library of Medicine), from each maker’s FDA drug listing. A few makers are shown, not every one. Never take a pill you can’t identify; ask a pharmacist.
Industry payments about this drug
No industry payments to clinicians named this drug in 2025.
Recalls and shortages
Not on the FDA drug shortage list.
No FDA-reported recalls since 2020.
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.