Hydroxyzine Hcl
Brand names: Hydroxyzine Hcl
At a glance
- Medicare prescriptions, 2024
- 3,690,919
- Medicare drug cost
- $59.5M
- Average cost per prescription
- $16.11
- Clinicians who prescribed it
- 119,046
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses and in histamine-mediated pruritus. As a sedative when used as a premedication and following general anesthesia, hydroxyzine may potentiate meperidine and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent. The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient.
From the FDA-approved prescribing information (label dated September 2024). Full labels on DailyMed (opens in a new tab)
Who prescribes it
- Family Medicine 25.0%
- Nurse Practitioners 20.4%
- Internal Medicine 14.7%
- Psychiatric Nurse Practitioners 13.2%
- Psychiatry 10.3%
- Physician Assistants 8.3%
- Dermatology 1.8%
- General Practice 0.9%
- Geriatric Medicine 0.8%
- Allergy & Immunology 0.7%
- Child & Adolescent Psychiatry 0.5%
- Neurology 0.4%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions rose 78% from 2019 to 2024.
Biggest change by state since 2019
- Michigan +128%
- Wisconsin +123%
- Utah +117%
- Illinois +112%
- Nevada +107%
- Mississippi (smallest change) +33%
- West Virginia (smallest change) +39%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
What it looks like
Pills from 4 makers on file. The same medicine can look different depending on who made it, so check the imprint (the letters and numbers on the pill) with your pharmacist if a refill looks different.
Advanced Rx Pharmacy of Tennessee, LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 50 mg | white round tablet, 7 mm | TV 309 |
Direct Rx
| Strength | Looks like | Imprint |
|---|---|---|
| 25 mg | white round tablet, 7 mm | H 501 |
| 25 mg | green round tablet, 8 mm | E160 |
| 25 mg | white round tablet, 6 mm | TV 308 |
Direct_rx
| Strength | Looks like | Imprint |
|---|---|---|
| 50 mg | white round tablet, 7 mm | 49 |
Imprimis Njof, LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 25 mg / 3 mg midazolam / 10 mg hydroxyzine hydrochloride | white round troche, 8 mm | |
Source: DailyMed (U.S. National Library of Medicine), from each maker’s FDA drug listing. A few makers are shown, not every one. Never take a pill you can’t identify; ask a pharmacist.
Industry payments about this drug
No industry payments to clinicians named this drug in 2025.
Recalls and shortages
Not on the FDA drug shortage list.
No FDA-reported recalls since 2020.
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.