Naloxone Hcl
Brand names: Naloxone Hcl, Narcan, Kloxxado
At a glance
- Medicare prescriptions, 2024
- 393,409
- Medicare drug cost
- $24.5M
- Average cost per prescription
- $62.27
- Clinicians who prescribed it
- 9,870
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
KLOXXADO is indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression, for adult and pediatric patients. KLOXXADO is intended for immediate administration as emergency therapy in settings where opioids may be present. KLOXXADO is not a substitute for emergency medical care.
From the FDA-approved prescribing information (label dated August 2025). Full labels on DailyMed (opens in a new tab)
Who prescribes it
- Nurse Practitioners 23.4%
- Pain Medicine 15.0%
- Physician Assistants 14.3%
- Family Medicine 10.5%
- Internal Medicine 7.3%
- Pediatrics 3.4%
- Pharmacists 2.8%
- Gastroenterology 2.8%
- Physical Medicine & Rehabilitation (PM&R) 2.6%
- Emergency Medicine 2.3%
- Orthopedic Surgery 2.2%
- Preventive Medicine & Public Health 1.9%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions rose 76% from 2019 to 2024.
Biggest change by state since 2019
- South Carolina +288%
- New York +237%
- Illinois +236%
- Missouri +172%
- Colorado +165%
- New Mexico (smallest change) −26%
- California (smallest change) +11%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
What it looks like
Pills from 2 makers on file. The same medicine can look different depending on who made it, so check the imprint (the letters and numbers on the pill) with your pharmacist if a refill looks different.
Amneal Pharmaceuticals LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 2 mg / 0.5 mg naloxone hydrochloride dihydrate | orange round tablet, 6 mm | A 14 |
| 8 mg / 2 mg naloxone hydrochloride dihydrate | orange round tablet, 11 mm | AN 415 |
Bryant Ranch Prepack
| Strength | Looks like | Imprint |
|---|---|---|
| 2 mg / 0.5 mg naloxone hydrochloride dihydrate | orange round tablet, 6 mm | A 14 |
Source: DailyMed (U.S. National Library of Medicine), from each maker’s FDA drug listing. A few makers are shown, not every one. Never take a pill you can’t identify; ask a pharmacist.
Industry payments about this drug
Drug makers reported $18,654 in payments to clinicians that named this drug in 2025 (meals, speaking, consulting and similar).
- Emergent Biosolutions Inc. $15,000
- Hikma Pharmaceuticals USA $3,654
Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor
Recalls and shortages
Not on the FDA drug shortage list.
No FDA-reported recalls since 2020.
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.