Naproxen
Brand names: Ec-Naproxen, Naproxen
At a glance
- Medicare prescriptions, 2024
- 2,003,702
- Medicare drug cost
- $23.8M
- Average cost per prescription
- $11.88
- Clinicians who prescribed it
- 74,397
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
Naproxen tablets are indicated for: the relief of the signs and symptoms of: • rheumatoid arthritis • osteoarthritis • ankylosing spondylitis • Polyarticular Juvenile Idiopathic Arthritis Naproxen tablets
From the FDA-approved prescribing information (label dated May 2026). Full labels on DailyMed (opens in a new tab)
Boxed warning
WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS Cardiovascular Thrombotic Events • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. • Naproxen Tablets are contraindicated in the setting of coronary artery bypass graft (CABG) surgery. Gastrointestinal Bleeding, Ulceration, and Perforation • NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious…
The FDA’s strongest warning on a label. It doesn’t mean the drug is unsafe for most people; talk to your doctor or pharmacist before stopping or changing any medicine.
Who prescribes it
- Family Medicine 30.6%
- Internal Medicine 18.9%
- Nurse Practitioners 16.2%
- Physician Assistants 9.9%
- Emergency Medicine 5.0%
- General Practice 3.2%
- Orthopedic Surgery 3.0%
- Rheumatology 2.1%
- Pain Medicine 1.6%
- Sports Medicine 1.3%
- Podiatrists 1.2%
- Neurology 0.8%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions fell 18% from 2019 to 2024.
Biggest change by state since 2019
- Nevada −3%
- Connecticut −9%
- Texas −10%
- New Jersey −10%
- Hawaii −10%
- South Dakota (smallest change) −32%
- Arkansas (smallest change) −31%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
What it looks like
Pills from 5 makers on file. The same medicine can look different depending on who made it, so check the imprint (the letters and numbers on the pill) with your pharmacist if a refill looks different.
Amazon.com Services LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 220 mg | blue round tablet, 10 mm | J 67 |
Bryant Ranch Prepack
| Strength | Looks like | Imprint |
|---|---|---|
| 550 mg | white capsule, 19 mm, scored to split in 2 | SG 433 |
Opmx LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 220 mg | blue oval tablet, 12 mm | 220 |
Redpharm Drug
| Strength | Looks like | Imprint |
|---|---|---|
| 500 mg | white capsule, 16 mm, scored to split in 2 | I15 |
St. Mary's Medical PArk Pharmacy
| Strength | Looks like | Imprint |
|---|---|---|
| 550 mg | white capsule, 19 mm, scored to split in 2 | SG 433 |
Source: DailyMed (U.S. National Library of Medicine), from each maker’s FDA drug listing. A few makers are shown, not every one. Never take a pill you can’t identify; ask a pharmacist.
Industry payments about this drug
No industry payments to clinicians named this drug in 2025.
Recalls and shortages
Not on the FDA drug shortage list.
4 recalls since 2020
- Apr 2026 · Acella Pharmaceuticals, LLC · Class II
Chemical contamination; presence of lead and lithium above specification - Mar 2025 · Glenmark Pharmaceuticals Inc., USA · Class II
CGMP Deviations - Nov 2023 · Glenmark Pharmaceuticals Inc., USA · Class II
Labeling: Label Mix-Up-Indomethacin bottles may be labeled as Naproxen - Aug 2021 · Glenmark Pharmaceuticals Inc., USA · Class II
CGMP Deviations
Recalls usually affect specific lots from one maker, not every version of a drug. Class I is the most serious; most drug recalls are Class II. FDA recalls (opens in a new tab)
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.