Oxycodone Hcl
Brand names: Oxycodone Hcl Er, Oxycontin, Roxicodone, Roxybond, Oxycodone Hcl
Part of: Opioid painkillers
At a glance
- Medicare prescriptions, 2024
- 8,403,613
- Medicare drug cost
- $399.3M
- Average cost per prescription
- $47.51
- Clinicians who prescribed it
- 145,806
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
Oxycodone hydrochloride is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve oxycodone hydrochloride for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products): Have not been tolerated or are not expected to be tolerated, Have not provided adequate analgesia or are not expected to provide adequate analgesia. Oxycodone hydrochloride should not be used for an extended period of time unless the pain remains severe enough to require an opioid analgesic and for which alternative treatment options continue to be inadequate.
From the FDA-approved prescribing information (label dated July 2025). Full labels on DailyMed (opens in a new tab)
Boxed warning
WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF OXYCODONE HYDROCHLORIDE Addiction, Abuse, and Misuse Because the use of oxycodone hydrochloride exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient's risk prior to prescribing and reassess all patients regularly for the development of these behaviors and conditions. Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of oxycodone hydrochloride, especially during initiation or following a dosage increase. To reduce the risk of respiratory depression, proper dosing and titration of oxycodone hydrochloride are essential. Accidental Ingestion Accidental ingestion of even one dose of oxycodone hydrochloride, especially by children, can result in a fatal overdose of oxycodone. Risks…
The FDA’s strongest warning on a label. It doesn’t mean the drug is unsafe for most people; talk to your doctor or pharmacist before stopping or changing any medicine.
Who prescribes it
- Nurse Practitioners 21.0%
- Physician Assistants 17.6%
- Family Medicine 13.6%
- Pain Medicine 12.0%
- Internal Medicine 10.6%
- Orthopedic Surgery 4.3%
- Physical Medicine & Rehabilitation (PM&R) 3.3%
- General Surgery 1.8%
- Hematology & Oncology 1.7%
- Anesthesiology 1.3%
- Emergency Medicine 1.2%
- Hospice & Palliative Medicine 1.1%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions rose 15% from 2019 to 2024.
Biggest change by state since 2019
- North Dakota +60%
- Iowa +55%
- Illinois +45%
- Nebraska +44%
- District of Columbia +40%
- West Virginia (smallest change) −9%
- Tennessee (smallest change) −8%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
What it looks like
Pills from 2 makers on file. The same medicine can look different depending on who made it, so check the imprint (the letters and numbers on the pill) with your pharmacist if a refill looks different.
Direct_rx
| Strength | Looks like | Imprint |
|---|---|---|
| 5 mg | white round tablet, 6 mm, scored to split in 2 | 4810 V |
Knoa Pharma LLC
| Strength | Looks like | Imprint |
|---|---|---|
| 10 mg | white round tablet, 7 mm | 10 OP |
| 15 mg | gray round tablet, 7 mm | 15 OP |
| 20 mg | pink round tablet, 7 mm | 20 OP |
| 30 mg | brown round tablet, 7 mm | 30 OP |
| 40 mg | yellow round tablet, 7 mm | 40 OP |
| 60 mg | red round tablet, 10 mm | 60 OP |
| 80 mg | green round tablet, 10 mm | 80 OP |
Source: DailyMed (U.S. National Library of Medicine), from each maker’s FDA drug listing. A few makers are shown, not every one. Never take a pill you can’t identify; ask a pharmacist.
Industry payments about this drug
Drug makers reported $82,483 in payments to clinicians that named this drug in 2025 (meals, speaking, consulting and similar).
- Protega Pharmaceutials Inc $82,483
Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor
Recalls and shortages
Not on the FDA drug shortage list.
4 recalls since 2020
- Jan 2026 · Amerisource Health Services LLC · Class II
Defective container: card seal defects (weak/non-existent seals), leading to the tablets falling out of their cavities. - Oct 2023 · Zyla Life Sciences US Inc. · Class III
Sub-potent Drug: Lower potency than labeled. - Dec 2021 · Lupin Pharmaceuticals Inc. · Class III
Out-of-specification impurity test result observed at 18-month long term stability time point. - Aug 2021 · Rhodes Pharmaceuticals, L.P. · Class II
Presence of Foreign Tablets/Capsules; A single foreign tablet Hydrochlorothiazide/Lisinopril 25/20 was found in one bottle
Recalls usually affect specific lots from one maker, not every version of a drug. Class I is the most serious; most drug recalls are Class II. FDA recalls (opens in a new tab)
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.