A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
Completed · Phase 2 · NCT01925261
Conditions: Knee Osteoarthritis
At a glance
- Research payments reported, 2025
- $2.5M
- U.S. investigators named
- 36
- Sites paid
- 23
- Planned or actual enrollment
- 120
About the trial
- Sponsor
- OrthoTrophix, Inc
- Tested
- TPX-100 50mg (drug), TPX-100 100mg (drug), TPX-100 200mg (drug), TPX-100 20mg (drug), Placebo (drug)
- Dates
- Started 2014-01; completion 2016-09
- Results posted
- Not yet
This one-year study is designed to investigate the safety and efficacy of TPX-100, a 23-amino acid chondrogenic peptide, delivered by intra-articular injection, in regeneration of knee cartilage in subjects with bilateral osteoarthritis of the knee.
From ClinicalTrials.gov, last updated 2017-04-21. Full record, eligibility and contacts (opens in a new tab)
Industry funding
American Regent reported $2.5M in research payments for this study in 2025 (34 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Russell D. Goode, MD Orthopedic Surgery · Mobile, AL
- Todd Bertoch, M.D. Anesthesiology · Prescott, AZ
- Dena E. Petersen, MD Family Medicine · Tucson, AZ
- Roxana Rodriguez, DO Internal Medicine · Tucson, AZ
- Natalia Chavez Stewart, M.D. Rheumatology · Corona, CA
- Manuchehr M. Darani, M.D. Gastroenterology · Santa Ana, CA
- Nathan Hammel, MD Orthopedic Surgery · Encinitas, CA
- Dan T. La, MD Rheumatology · Tujunga, CA
- Chandrakant V. Mehta, M.D. Specialist · Hemet, CA
- Samy K. Metyas, MD Rheumatology · Covina, CA
- Tien I K. Su, M.D. Rheumatology · Whittier, CA
- Frank C. Alvarez Li, M.D. General Practice · Hialeah, FL
- Eddie Armas, MD General Practice · South Miami, FL
- Abid H. Chaudhry, M.D. Emergency Medicine · Homestead, FL
- Brandon Lenox, D.O. Anesthesiology · Maitland, FL
- Ramon Moreda, M.D. Rheumatology · Coral Gables, FL
- Ramses Vega, M.D. Internal Medicine · Miami, FL
- Marvin D. Tark, MD Pain Medicine · Marietta, GA
- Neil A. Segal, MD Physical Medicine & Rehabilitation (PM&R) · Iowa City, IA
- Martha S. Fanning, M.D. Emergency Medicine · Overland Park, KS
- Mark S. Adams, M.D. Internal Medicine · London, KY
- William B. Smith, M.D. Specialist · New Orleans, LA
- Brennan J. Boettcher, D.O. Sports Medicine · Rochester, MN
- Leonardo Kapural, M.D. Pain Medicine · Winston Salem, NC
- Satkirin Khalsa Family Medicine · Albuquerque, NM
- Alton J. Walters, MD Internal Medicine · Las Vegas, NV
- Ernest C. Lee, M.D., M.P.H. Family Medicine · Tinker Afb, OK
- Steven S. Sands, D.O. Orthopedic Surgery · Oklahoma City, OK
- Thomas J. Ellis, D.O. Sports Medicine · State College, PA
- Shawn C. Saylor, D.O. Sports Medicine · Altoona, PA
- Howsen Kwan, M.D. Family Medicine · Rocksprings, TX
- Sabeen Najam, MD Rheumatology · Baytown, TX
- Neeraj B. Shah, M.D. Internal Medicine · Austin, TX
- Daneshvari R. Solanki, FFARCS Anesthesiology · League City, TX
- Oscar D. Taunton JR., MD Orthopedic Surgery · Bedford, TX
- David C. Larsen, MD Family Medicine · Salt Lake City, UT
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Biovin Enterprise LLC $488,749
- Well Pharma Medical Research, Corp $275,572
- Wasatch Clinical Research $169,651
- University Orthopedics Center $142,110
- Albuquerque Clinical Trials, Inc. $140,141
- Erg Holding Company LLC $140,056
- Las Mercedes Medical Research $137,841
- K2 Medical Research LLC $123,640
- Alliance for Multispecialty Research, LLC $123,237
- Clinitiative $119,642
- Noble Clinical Research, LLC $111,111
- Jbr Clinical Research LLC $98,992
- Marvel Clinical Research 002 LLC $93,981
- Clinrx Research LLC $89,966
- Texas Orthopedic Specialists, PLLC $64,377
- University of Kansas Medical Center Research Institute, Inc. $51,195
- Las Vegas Clinical Trials LLC $35,245
- San Dieguito Orthopedic Medical Center $33,348
- Phoenix Clinical Trials $30,673
- Mayo Clinic Hospital Rochester, MN $22,660
- The Center for Clinical Research, LLC $15,847
- Drug Studies America $10,966
- Accurant Clinical Management, LLC $10,955
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.