A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
Active, not recruiting · Phase 3 · NCT03006068
Conditions: Ulcerative Colitis (UC)
At a glance
- Research payments reported, 2025
- $562,657
- U.S. investigators named
- 45
- Sites paid
- 46
- Planned or actual enrollment
- 950
About the trial
- Sponsor
- AbbVie
- Tested
- Upadacitinib (ABT-494) (drug), Placebo (drug)
- Dates
- Started 2017-01-31; completion 2027-07
- Results posted
- Not yet
This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.
From ClinicalTrials.gov, last updated 2026-01-12. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $562,657 in research payments for this study in 2025 (205 payments).
Products named: Rinvoq
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Charles E. Johnson, M.D. Gastroenterology · Mobile, AL
- John J. Hong, MD Gastroenterology · Fallbrook, CA
- Hyun S. Kim, MD Gastroenterology · San Diego, CA
- Karen Simon, M.D. Gastroenterology · Oxnard, CA
- Mark R. Fleisher Gastroenterology · Jacksonville, FL
- Paul A. Hellstern, M.D. Gastroenterology · Crystal River, FL
- Henry Levine, MD Gastroenterology · Orlando, FL
- Andria M. Mushahwar, MD Gastroenterology · Maitland, FL
- Shahriar Sedghi, M.D. Gastroenterology · Macon, GA
- Marie L. Walton, MD, MPH Research Clinic/Center · Riverdale, GA
- Eugene Greenberg, MD Gastroenterology · Urbana, IL
- Heather M. Prendergast Emergency Medicine · Chicago, IL
- Curtis A. Baum, MD Gastroenterology · Topeka, KS
- Humberto I. Aguilar, M.D. Gastroenterology · Shreveport, LA
- Ronald Fogel, MD Gastroenterology · Chesterfield, MI
- Peter D. Higgins, MD, PHD Gastroenterology · Ann Arbor, MI
- Ali Yazdani, M.D. Gastroenterology · Ypsilanti, MI
- Edward V. Loftus JR., M.D. Gastroenterology · Rochester, MN
- Anas K. Gremida, MD Gastroenterology · Saint Louis, MO
- Richard S. Bloomfeld, MD Gastroenterology · Winston Salem, NC
- Nilesh I. Lodhia, MD Gastroenterology · Charlotte, NC
- Hoadley H. Harris, M.D. Family Medicine · Fargo, ND
- Barry P. Kaufman, MD Gastroenterology · Egg Harbor Township, NJ
- Christian D. Stone, MD, MPH Gastroenterology · Las Vegas, NV
- Jonathan I. Goldstein, M.D. Gastroenterology · Rochester, NY
- Igor Grosman, D.O. Gastroenterology · Brooklyn, NY
- Thomas A. Ullman, M.D. Gastroenterology · Scarsdale, NY
- Pradeep Kumar T. Bekal, M.D. Gastroenterology · Cincinnati, OH
- Loren P. Brook, M.D. Gastroenterology · Cincinnati, OH
- Donald L. Mcneil, MD Allergy & Immunology · Columbus, OH
- David S. Stokesberry, M.D. Gastroenterology · Oklahoma City, OK
- Harvey A. Tatum, MD Gastroenterology · Tulsa, OK
- Michael J. Georgetson, MD Gastroenterology · Sayre, PA
- Esther A. Torres, M.D. Gastroenterology · San Juan, PR
- Matthew R. Barnes, MD Gastroenterology · Greenville, SC
- Ziad H. Younes, M.D. Gastroenterology · Germantown, TN
- Mohammad T. Al-assi, M.D. Gastroenterology · Arlington, TX
- Jeff Bullock, M.D. Gastroenterology · San Antonio, TX
- George A. Duvall, M.D. Gastroenterology · Tyler, TX
- Harry S. Ojeas, MD Gastroenterology · Houston, TX
- Harry E. Sarles, M.D. Gastroenterology · Rockwall, TX
- Philip Ginsburg, MD Gastroenterology · Rutland, VT
- Jason P. Etzel, MD Gastroenterology · Vancouver, WA
- Timothy L. Zisman, MD, MPH Gastroenterology · Seattle, WA
- Brian F. Moloney, MB BCH MD Gastroenterology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Mayo Clinic Rochester $38,852
- Las Vegas Medical Research LLC $37,586
- Cb Flock Research Corporation $35,740
- Tyler Research Institute LLC $29,535
- UC Healthcare System $25,633
- Nature Coast Clinical Research $25,383
- West Coast Clinical Trials LLC $24,605
- Louisiana Research Center LLC $22,262
- Temecula Valley Digestive Disease Consultants Amc DBA United Gastroenterologists $21,014
- Fomat Medical Research $20,502
- Optimed Research LTD $18,945
- Donald Guthrie Foundation for Educa $18,213
- Southern Star Research Institute LLC $16,824
- Washington Univ in St Louis $14,483
- Wisconsin Center for Advanced Research $13,573
- Medical Research Center of Connecticut $11,631
- Gastroenterology Associates PA $11,245
- Cfagi LLC $11,052
- Cotton O Neil Clinic Revocable Trust DBA Cotton O Neil Clinical Research Center Digestive Health; A $10,948
- Universidad De Pr-Esc Farmacia $10,673
- Gastroenterology Associates of Central Georgia LLC $9,678
- Topography Health Inc $9,564
- Benaroya Research Institute $9,279
- Vilo Research Group Inc $9,050
- Plains Clinical Research Center LLC $9,046
- Carle Foundation Hospital, IL $8,983
- Medical Associates Research Group $8,978
- Encore Borland-Groover Clinical Research LLC $8,913
- Endoscopic Research Inc $8,341
- Rochester Gastroenterology $8,277
- Texas Clinical Research Institute L $8,117
- The Vancouver Clinic Inc Ps $6,485
- Gastroenterology Center Of $5,538
- Digestive Disease Specialists Inc $5,241
- Wake Forest University $4,544
- Carolinas Medical Center-Northeast, NC $4,282
- Gcga Physicians Inc $4,000
- University of Michigan Health System, MI $3,900
- Digestive Health Associates of Texas PA $3,873
- Next Innovative Cinical Research $3,000
- Cooper University Hospital, NJ $1,284
- Clinical Research Institute of Michigan LLC $1,229
- Infinite Clinical Trials $839
- Biomedical Research Alliance of New York $659
- Options Health Research LLC $428
- Ny Scientific Corp $428
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.