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A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

Active, not recruiting · Phase 3 · NCT03568318

Conditions: Atopic Dermatitis

At a glance

Research payments reported, 2025
$729,276
U.S. investigators named
62
Sites paid
59
Planned or actual enrollment
1,533

About the trial

Sponsor
AbbVie
Tested
Placebo (drug), Upadacitinib (drug), Topical corticosteroids (TCS) (drug)
Dates
Started 2018-08-09; completion 2030-10-23
Results posted
Yes

The objective of this study is to assess the efficacy and safety of upadacitinib combined with topical corticosteroids (TCS) for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

From ClinicalTrials.gov, last updated 2025-12-23. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $729,276 in research payments for this study in 2025 (367 payments).

Products named: Rinvoq

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Gcm Medical Group Psc $94,905
  • T Joseph Raoof MD Inc $61,056
  • Dartmouth Hitchcock Health $34,251
  • Indiana University $29,965
  • Clinical Research Puerto Rico Inc $27,218
  • Oregon Med Research Ctr PC $25,654
  • First Oc Dermatolgy Research Inc $24,551
  • The Board of Trustees of the Leland $22,374
  • Dermatology Treatment And $18,336
  • Western States Clinical $17,994
  • Montefiore Medical Center $17,718
  • Velocity Clinical Research Inc $17,542
  • Dr Samuel Sanchez Psc $17,175
  • Clinical Research of West Florida $16,662
  • Howland Allergy & Asthma PLLC $15,215
  • Alliance Dermatology & Mohs Center $14,388
  • University of California Davis Medical Center, CA $14,159
  • Skin Care Research Inc $13,709
  • Uci Health-Orange, CA $13,410
  • Ohsu Hospital and Clinics, OR $12,091
  • Gsi Clinical Research LLC $11,668
  • Dermatologists of Sw Ohio LLC $11,436
  • Academic Alliance in Derm LLC $11,245
  • University of Pittsburgh Physicians $10,829
  • Clinical Research Center $10,330
  • Odrc Enterprises LLC $10,174
  • Tufts Medical Center, MA $9,445
  • Center for Clinical Studies LTD LLP $9,319
  • Marietta Dermatology Clinical $9,113
  • Total Skin & Beauty Dermatology Cen $8,566
  • Forward Clinical Trials Inc $8,226
  • Alma M Cruz-Santana $7,914
  • Northshore University Healthsystem - Evanston Hospital, IL $7,585
  • Modern Research Associates PLLC $7,421
  • Dawes Fretzin Clinical Research $7,284
  • Allergy & Asthma Associates Of $6,948
  • Arkansas Research Trials LLC $5,761
  • Investigate MD LLC $5,470
  • Clinical PArtners LLC $4,888
  • Northwestern University $4,821
  • Southwest Skin Specialists LLC $4,654
  • Allcutis Research LLC $4,600
  • Skin Specialists PC $4,359
  • Ponce Medical School Foundation Inc $4,250
  • Studies in Dermatology LLC $3,765
  • Univ Clinical Research-Deland LLC $3,502
  • Great Lakes Clinical Trials LLC DBA Flourish Research $3,395
  • Arizona Research Center Inc $3,268
  • Arlington Research Center Inc $3,118
  • Michigan Center for Research $3,024
  • Clinical Research Institute Of $2,414
  • Beacon Clinical Research LLC $2,231
  • Vital Prospects Clinical Research $2,131
  • Savin Medical Group LLC $2,059
  • Miami Dade Medical Research Institu $2,024
  • Bellaire Dermatology Associates $2,020
  • Accellacare US Inc $750
  • Dermatology Trial Associates $591
  • Florida Academic Centers $306

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.