A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
Enrolling by invitation · Phase 3 · NCT03683186
Conditions: PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease
At a glance
- Research payments reported, 2025
- $574,924
- U.S. investigators named
- 45
- Sites paid
- 44
- Planned or actual enrollment
- 1,000
About the trial
- Sponsor
- United Therapeutics
- Tested
- Ralinepag (drug)
- Dates
- Started 2019-09-23; completion 2026-12
- Results posted
- Not yet
Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.
From ClinicalTrials.gov, last updated 2026-10-06. Full record, eligibility and contacts (opens in a new tab)
Industry funding
United Therapeutics Corporation reported $574,924 in research payments for this study in 2025 (196 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Jose Tallaj Heart Failure & Transplant Cardiology · Birmingham, AL
- Bhuvin M. Buddhdev, MD Pulmonology · Phoenix, AZ
- Franz Rischard, DO Internal Medicine · Tucson, AZ
- Adam J. Brownstein, MD Pulmonology · Los Angeles, CA
- Timothy M. Fernandes, MD Pulmonology · La Jolla, CA
- Sivagini Ganesh, M.D. Pulmonology · Los Angeles, CA
- Jeffrey S. Sager, MD Pulmonology · Santa Barbara, CA
- Rajan Saggar, MD Pulmonology · Los Angeles, CA
- Shelley M. Shapiro, MD Pulmonology · Los Angeles, CA
- Namita Sood, M.D. Pulmonology · Sacramento, CA
- Bassam Yaghmour, M.D. Critical Care Medicine · Orange, CA
- Roham T. Zamanian, MD Pulmonology · Stanford, CA
- David Badesch, MD Pulmonology · Aurora, CO
- Marjorie P. George, MD Pulmonology · Denver, CO
- Roger A. Alvarez, D.O., M.P.H. Pulmonology · Weston, FL
- Ali Ataya, M.D. Critical Care Medicine · Gainesville, FL
- Charles Burger, MD Pulmonology · Jacksonville, FL
- Daniel T. Layish, M.D. Pulmonology · Orlando, FL
- Stacy A. Mandras, MD Heart Failure & Transplant Cardiology · Orlando, FL
- Jinesh Mehta, M.D. Pulmonology · Weston, FL
- Micah R. Fisher, MD Pulmonology · Atlanta, GA
- Linda M. Cadaret, MD Heart Failure & Transplant Cardiology · Iowa City, IA
- Ashish Haryani, MD Heart Failure & Transplant Cardiology · Elk Grove Village, IL
- Ashwin K. Ravichandran, MD Heart Failure & Transplant Cardiology · Indianapolis, IN
- Elizabeth S. Klings, M.D. Pulmonology · Boston, MA
- Gautam V. Ramani, MD Heart Failure & Transplant Cardiology · Baltimore, MD
- Reda E. Girgis, MD Pulmonology · Grand Rapids, MI
- Murali M. Chakinala, MD Pulmonology · Saint Louis, MO
- Terry A. Fortin, MD Cardiology · Durham, NC
- Lana Melendres-groves, MD Pulmonology · Albuquerque, NM
- Daniel J. Lachant, D.O. Pulmonology · Rochester, NY
- Roxana Sulica, M.D., Critical Care Medicine · New York, NY
- Jean M. Elwing, MD Pulmonology · Cincinnati, OH
- Veronica Franco, MD Heart Failure & Transplant Cardiology · Columbus, OH
- Lianne L. Lin, MD Pulmonology · Beaverton, OR
- Jeffrey C. Robinson, M.D. Pulmonology · Portland, OR
- Jason S. Fritz, MD Critical Care Medicine · Philadelphia, PA
- Amresh Raina, MD Heart Failure & Transplant Cardiology · Pittsburgh, PA
- Michael Scharf, MD Pulmonology · Philadelphia, PA
- Sonja D. Bartolome, M.D. Pulmonology · Dallas, TX
- Chetan A. Naik, M.D. Pulmonology · Dallas, TX
- Bela Patel, M.D. Pulmonology · Houston, TX
- Raju M. Reddy, M.D. Pulmonology · Austin, TX
- Zeenat Safdar, MD Pulmonology · Houston, TX
- Kenneth Presberg, MD Pulmonology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Ronald Reagan UCLA Medical Center, CA $56,161
- Strong Memorial Hospital, NY $54,756
- Baylor Research Institute $43,258
- The Methodist Hospital Research Institute $34,150
- Corewell Health $26,850
- Hospital of Univ of Pennsylvania, PA $25,548
- St Josephs Hospital and Medical Center, AZ $22,611
- University of Florida $20,799
- Regents of the University of Colorado $20,754
- Cleveland Clinic Florida $19,041
- The Regents of the University of California $17,981
- Duke University Department of Medicine $17,677
- The Ohio State University $16,589
- The University of Texas Southwestern Medical Center $16,500
- Trustees of Boston University $13,657
- The Board of Trustees of the Leland Stanford Junior University $13,148
- Ohsu Hospital and Clinics, OR $11,369
- Uci Health-Orange, CA $11,186
- The University of Maryland Baltimore $10,611
- Central Florida Pulmonary Group P A $10,315
- University of Southern California $9,997
- Mayo Clinic Jacksonville $9,489
- Medical College of Wisconsin Inc $8,788
- University of New Mexico Hsc $8,512
- The Washington University $8,411
- Ascension Seton Medical Center Austin, TX $8,220
- The University of Arizona $7,929
- Adventhealth Orlando, FL $7,825
- University of Iowa Hospital & Clinics, IA $6,458
- Alexian Brothers Health System $4,954
- Allegheny Singer Research Institute $3,550
- Central Indiana Health Services Cardiac Services, Inc $3,383
- Emory University Hospital, GA $3,315
- National Jewish Health, CO $3,249
- University of Miami $3,014
- University of California Davis Medical Center, CA $2,497
- Jeffrey S. Sager, MD Medical Corporation $2,372
- University of Alabama Hospital, AL $2,210
- University of Cincinnati Physicians Company, LLC $2,193
- The University of Texas Health $2,106
- The Oregon Clinic PC $1,260
- Greater Los Angeles Veterans Research and Education Foundation $967
- Thomas Jefferson University $800
- NYU Grossman School of Medicine $463
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.