A Study of Oral Venetoclax Tablets and Oral Azacitidine as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy
Completed · Phase 3 · NCT04102020
Conditions: Acute Myeloid Leukemia (AML)
At a glance
- Research payments reported, 2025
- $22,052
- U.S. investigators named
- 6
- Sites paid
- 6
- Planned or actual enrollment
- 112
About the trial
- Sponsor
- AbbVie (with Roche-Genentech)
- Tested
- Venetoclax (drug), Azacitidine (drug), Azacitidine (drug)
- Dates
- Started 2020-03-26; completion 2026-02-20
- Results posted
- Yes
This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in combination with azacitidine (AZA). Part 3 will be the Dose Finding portion to determine RPTD of venetoclax in combination with AZA. Part 2 and Part 3 Randomization of the study were removed.
From ClinicalTrials.gov, last updated 2026-04-08. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $22,052 in research payments for this study in 2025 (7 payments).
Products named: Venclexta
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Muthu V. Kumaran, M.D. Medical Oncology · Little Rock, AR
- Maxim Norkin, MD, PHD Hematology · Jacksonville, FL
- Amy Y. Wang, M.D. Family Medicine · Chicago, IL
- James K. Mccloskey II, M.D. Medical Oncology · Hackensack, NJ
- Dale Schaar Medical Oncology · New Brunswick, NJ
- Noridza Rivera-rodriguez Hematology & Oncology · San Juan, PR
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Rutgers the State University $10,000
- Pan American Center for Oncology Trials LLC $5,506
- Baptist Health Medical Center - Jacksonville, FL $2,300
- Northshore University Healthsystem - Evanston Hospital, IL $2,000
- Hackensack University Medical Center, NJ $1,726
- University of Arkansas Medical Sciences, AR $520
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.