A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma
Completed · Phase 1, Phase 2 · NCT04238819
Conditions: Relapsed Solid Tumor, Refractory Solid Tumor
At a glance
- Research payments reported, 2025
- $130,231
- U.S. investigators named
- 6
- Sites paid
- 6
- Planned or actual enrollment
- 47
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Abemaciclib (drug), Irinotecan (drug), Temozolomide (drug), Dinutuximab (drug), GM-CSF (drug)
- Dates
- Started 2020-11-09; completion 2025-08-19
- Results posted
- Yes
The study's purpose is to see if the drug, abemaciclib, is safe and effective when given with other drugs to kill cancer cells. The study is open to children and young adults with solid tumors, including neuroblastoma, that did not respond or grew during other anti-cancer treatment. For each participant, the study is estimated to last up to 2 years.
From ClinicalTrials.gov, last updated 2026-03-02. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $130,231 in research payments for this study in 2025 (6 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Lindsey M. Hoffman, D.O. Pediatric Hematology & Oncology · Aurora, CO
- Melissa K. Bear, M.D. Pediatric Hematology & Oncology · Indianapolis, IN
- David J. Hoogstra, MD Pediatric Hematology & Oncology · Grand Rapids, MI
- Thomas B. Russell, MD Pediatrics · Charlotte, NC
- Jenna D. Wise, PA-C Physician Assistants · Kettering, OH
- Frank M. Balis, M.D. Pediatric Hematology & Oncology · Philadelphia, PA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Corewell Health $76,183
- Carolinas Medical Center-Northeast, NC $37,233
- Indiana University $8,140
- Phoenix Children's Hospital, AZ $7,500
- Children's Hospital of Philadelphia, PA $675
- Akron Children's Hospital, OH $500
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.