Skip to main content

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Completed · Phase 3 · NCT04255433

Conditions: Type 2 Diabetes Mellitus

At a glance

Research payments reported, 2025
$5.6M
U.S. investigators named
130
Sites paid
133
Planned or actual enrollment
13,299

About the trial

Sponsor
Eli Lilly and Company
Tested
Tirzepatide (drug), Dulaglutide (drug)
Dates
Started 2020-05-29; completion 2025-06-12
Results posted
Yes

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

From ClinicalTrials.gov, last updated 2026-07-08. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $5.6M in research payments for this study in 2025 (249 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Palm Research Center Inc $182,982
  • Valley Clinical Trials Inc $177,731
  • Capital Area Research LLC $143,846
  • Cleveland Clinic, OH $136,706
  • Tri State Medical Group Inc $130,583
  • Cardiology PArtners Clinical $126,965
  • Thomas Jefferson University $125,219
  • Advanced Clinical Research LLC $124,318
  • Healtheast Medical Research Institute $118,684
  • John Muir Med Fndtn DBA John Muir Phys Network $116,066
  • Nebraska Educational Biomedical $113,853
  • Cotton Oneil Msd of Stormont Vail Healthcare $105,369
  • Spectrum Clinical Research Inc $104,472
  • Encore Medical Research, LLC $103,956
  • Prairie Education and Research Coop $103,533
  • Manati Medical for Clinical Research $103,378
  • Duke University $99,577
  • East Coast Institute for Research $89,811
  • Research and Cardiovascular $88,848
  • Regents of the University of Colorado $88,297
  • Ivy Joan E Madu MD $87,871
  • Peace River Cardiovascular Center $85,163
  • Morgan Medical Management and Consultants Inc $83,554
  • Arcturus Healthcare PLC, Troy Internal $82,133
  • Los Angeles Biomedical $79,260
  • Gcm Medical Group Psc $76,241
  • Southern Endocrinology Associates PA $74,982
  • North Hills Medical Research $74,513
  • Northwest Houston Clinical Research PLLC $71,897
  • Piedmont Medical Research Associates Inc $69,943
  • Excel Medical Clinical Trials, LLC $65,604
  • Tribe Clinical Research LLC $65,109
  • Md Medical Research $64,007
  • Foundation for Advancing Veterans Health Research $63,449
  • Unehealth $60,671
  • University of Iowa Hospital & Clinics, IA $58,147
  • Horizon Clinical Research Group $56,687
  • Billings Clinic Hospital, MT $54,664
  • Diabetes and Thyroid Center $54,663
  • Preferred Primary Care Physicians Inc $52,793
  • St Johns Medical Research Institute Inc $52,726
  • Joslin Diabetes Center Inc $52,318
  • Clinical Investigation Specialists Inc $49,327
  • Cedar Crosse Research Center $49,051
  • Iowa Diabetes and Endocrinology Rsrch Cntr $48,513
  • Elite Clinical Trials Lllp $46,827
  • Academy of Diabetes Thyroid & Endocrine $46,820
  • Chase Medical Research LLC $46,239
  • Clincial Research of Central Florida $45,004
  • Orlando Heart & Vascular Institute, LLC $44,278
  • Clinvest Headlands LLC $43,525
  • Albany Medical College $43,173
  • Kaiser Foundation Health Plan Inc $42,832
  • Atlanta Diabetes Associates $42,198
  • Charleston Research Institute $41,844
  • Diabetes and Endocrinology Consultants of Pennsylvania, LLC $41,831
  • Carolinas Medical Center-Northeast, NC $40,440
  • Deaconess Medical Center, WA $39,782
  • Nsc Research Inc $39,566
  • Studymetrix Research LLC $38,360
  • Qualmedica Research LLC $37,263
  • Rocky Mountain Clinical Research LLC $33,750
  • Osvaldo A Brusco MD $33,728
  • Dallas Diabetes and Endo Research Center PA $33,345
  • Central Washington Health Services $32,533
  • Brigham and Women's Hospital, MA $32,402
  • Seattle Institute for Biomed and Clinical Rsrch $30,512
  • Medstar Health Research Institute $30,324
  • Univ of Kansas Med Cntr Rsrch Institute $30,152
  • Great Lakes Medical Research LLC $29,519
  • Elixia Phc LLC $29,477
  • Alliance for Multispecialty Research Lls $28,682
  • Physicians Research $27,722
  • Sivalingam Medical Corporation Inc $27,721
  • Northwest Heart Clinical Research LLC $27,346
  • Lillestol Research LLC $26,549
  • Consano Clinical Research LLC $25,240
  • Holston Medical Group PC $24,956
  • Medical Education & Research Foundation Inc $24,103
  • Regents of the University of California $23,431
  • Atlanta Heart Specialists LLC $22,012
  • Galenos Research $21,618
  • North Texas Endocrine Ctr PA $21,337
  • Louisville Metabolic $20,948
  • Monument Health Rapid City Hospital, SD $20,159
  • Cardiology Consultants of Philadelphia $19,721
  • University of Alabama Hospital, AL $18,757
  • Wasatch Clinical Research $17,986
  • David Fitzpatrick MD DBA E West Med Rsrch $17,894
  • Centracare - St. Cloud Hospital, MN $16,698
  • Research Institute of Dallas $16,169
  • Helena W Rodbard, MD, PA $15,147
  • North Hills Medical Research, Inc $14,058
  • Leading Edge Research $12,648
  • Sandhill Research LLC $11,459
  • Activmed Practices and Research LLC $11,442
  • Riverside University Health System-Medical Center, CA $10,968
  • Monterey Endocrine and Diabetes Institute Inc $10,019
  • Headlands Research California LLC $9,948
  • Foundation Medical PArtners Inc $9,281

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.