A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
Recruiting · Phase 4 · NCT04375033
Conditions: Opioid Use Disorder
At a glance
- Research payments reported, 2025
- $7,784
- U.S. investigators named
- 6
- Sites paid
- 6
- Planned or actual enrollment
- 952
About the trial
- Sponsor
- VA Office of Research and Development
- Tested
- Sublingual buprenorphine with naloxone (drug), Injectable subcutaneous buprenorphine (drug)
- Dates
- Started 2020-11-03; completion 2029-05-31
- Results posted
- Not yet
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300 milligrams (mg) is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorphine formulation at a target dose of 4-32 mg (standard of care). This is an open-label, randomized, controlled trial including 952 Veterans with opioid use disorder (OUD) recruited over 7 years and followed actively for 52 weeks. There are a number of secondary objectives that will be studied as well and include: comorbid substance use, both non-fatal and fatal opioid overdose, HIV and Hepatitis …
From ClinicalTrials.gov, last updated 2026-09-10. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Indivior Inc. reported $7,784 in research payments for this study in 2025 (12 payments).
Products named: Sublocade
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Geetha Shivakumar, M.D. Psychiatry · Cupertino, CA
- Maha Lahoud-bladykas, M.D. Psychiatry · Bay Pines, FL
- Leonardo Rodriguez, MD Psychiatry · Gainesville, FL
- Kyle M. Kampman, MD Psychiatry · Philadelphia, PA
- Ajay Manhapra, M.D. Addiction Medicine · Hampton, VA
- Matthew E. Stohs, MD Psychiatry · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Veterans Admin Med Ctr Bay Pines Vahcs $1,947
- Veterans Affairs Medical Ctr $1,507
- Veterans Administration Vamc - Medical Center $1,452
- Clement J Zablocki VA Med Ctr Vamc $1,285
- Dallas VA Medical Center VA North Texas Health Care System $1,228
- VA Hospital Corporal Michael J Crescenz VA Medical Center $366
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.