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Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease

Completed · Phase 2, Phase 3 · NCT04429503

Conditions: Diabetic Macular Edema, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus

At a glance

Research payments reported, 2025
$4.2M
U.S. investigators named
86
Sites paid
81
Planned or actual enrollment
660

About the trial

Sponsor
Regeneron Pharmaceuticals (with Bayer)
Tested
aflibercept (drug), High-dose aflibercept (drug)
Dates
Started 2020-06-29; completion 2024-06-18
Results posted
Yes

The primary objective of the study is to determine if treatment with high-dose aflibercept (HD) at intervals of 12 or 16 weeks provides non-inferior best corrected visual acuity (BCVA) compared to aflibercept dosed every 8 weeks. The secondary objectives of the study are as follows: * To determine the effect of HD vs. aflibercept on anatomic and other visual measures of response * To evaluate the safety, immunogenicity, and pharmacokinetics (PK) of aflibercept

From ClinicalTrials.gov, last updated 2025-08-08. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Regeneron Pharmaceuticals, Inc. reported $4.2M in research payments for this study in 2025 (11,532 payments).

Products named: Eylea Hd

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Pinnacle Research Institute Inc $226,378
  • Salehi Retina Institute $185,798
  • Charleston Neuroscience Institute LLC $182,089
  • East Florida Eye Institute $165,217
  • University Retina and Macula Associates PC $160,135
  • Mid Atlantic Retina Specialists $154,839
  • The Retina PArtners $144,561
  • California Eye Specialists Medical Group Inc $139,440
  • Emanuelli Research and Development Center LLC $132,920
  • Florida Retina Institute $120,122
  • Retina Consultants of Texas $118,644
  • Tennessee Retina PC $117,175
  • Tulsa Retina Consultants PLLC $101,273
  • Ophthalmic Consultants of Boston $89,236
  • Retina Consultants of Hawaii Research Account $89,213
  • Blue Ocean Clinical Research Center LLC $83,164
  • Retina Group of New England PC $80,673
  • Pautler Cohen Findlay and Eichenbaum MDs PA $79,051
  • Retina Vitreous Center PLLC $71,811
  • Eyehealth Northwest PC $62,531
  • Carson Mcbeath and Boswell Inc $60,713
  • Black Hills Regional Eye Institute LLP $59,745
  • Long Island Vitreoretinal Consultants $58,446
  • Florida Eye Associates Inc $57,969
  • Retina Vitreous Associates Medical Group $56,476
  • Southeast Retina Center PC $54,638
  • $53,199
  • Prairie Eye Center LTD $52,201
  • Florida Retina Consultants $51,015
  • Joseph R Martel MD Inc $50,705
  • Strategic Clinical Research Group LLC $48,497
  • Ophthalmic Consultants of Long Island $48,462
  • American Institute of Research $47,685
  • Retina Associates of Cleveland Inc $44,626
  • Deep Blue Retina Clinical Research PLLC $42,317
  • Envision Ocular LLC $41,888
  • Eye Associates of Pinellas $37,834
  • Vitreous and Retina Consultants PA $36,385
  • Retina Vitreous Surgeons of Central Ny PC $35,201
  • Southern California Permanente Medical Group $33,738
  • Cincinnati Eye Institute $33,297
  • Win Retina $32,988
  • Total Practice Management $32,655
  • Fort Wayne Retina P C $31,554
  • Pamela A Weber MD PC $31,013
  • Georgia Retina P C $30,481
  • Retina Macula Specialists of Miami LLC $29,927
  • Midwest Retina Inc $29,859
  • Charlotte Eye Ear Nose and Throat Associates PA $29,807
  • Southeastern Retina Associates PC $29,705
  • National Ophthalmic Research Institute $28,990
  • Springfield Clinic LLP $28,361
  • Retina Consultants San Diego Inc $25,466
  • Retina Consultants of Nevada $21,908
  • Retina Consultants of Southern Colorado PC $18,944
  • Southwest Retina Research Center $18,438
  • Mid Atlantic Retina $17,943
  • Retina Vitreous Consultants LLP $17,853
  • Retina Associates PA $16,528
  • Meridian Clinical Research Llc-Omaha $14,691
  • Retina Consultants of Orange County Inc $13,832
  • Associated Retinal Consultants PC $13,651
  • Coloradoretinaassociatespc $13,042
  • Retinal Consultants of San Antonio PA $12,760
  • Charles Retina Institute PC $12,667
  • Arizona Retina and Vitreous Research $12,095
  • Palmetto Retina Center LLC $11,734
  • Eye Care Specialists PC $11,440
  • West Virginia University $10,960
  • Wagner Macula and Retina Center $10,412
  • Eye Institute of West Florida $10,374
  • Marietta Eye Clinic $10,096
  • Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center $10,071
  • Rocky Mountain Retina Consultants $9,718
  • Fort Lauderdale Eye Institute LLC $8,715
  • Colorado Retina Associates PC $7,238
  • Retina Research Institute of Texas $6,874
  • Western Carolina Clinical Research LLC $6,746
  • Retina Vitreous Consultants $5,517
  • California Retina Consultants $4,088
  • Board of Trustees of the Leland Stanford Junior University $1,340
  • Vision Innovation Centers of Pennsylvania LLC $1,000

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.