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A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

Active, not recruiting · Phase 3 · NCT04437511

Conditions: Alzheimer Disease

At a glance

Research payments reported, 2025
$8.4M
U.S. investigators named
141
Sites paid
151
Planned or actual enrollment
1,736

About the trial

Sponsor
Eli Lilly and Company
Tested
Donanemab (drug), Placebo (drug)
Dates
Started 2020-06-19; completion 2028-11
Results posted
Yes

The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease. Additional participants will be enrolled to an addendum safety cohort. The participants will be administered open-label donanemab. Trial participants who were dosed with donanemab in the main study will be enrolled to a 3-year follow up addendum. No study drug will be administered during this follow up.

From ClinicalTrials.gov, last updated 2026-08-26. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $8.4M in research payments for this study in 2025 (228 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Kerwin Memory Center LLC $2.2M
  • Optimus U $1.5M
  • Ips Research Company $435,182
  • Gwinnett Research Institute LLC $319,478
  • Charter Research LLC $179,013
  • Gadolin Research LLC $166,733
  • Pharmacology Research Institute $156,992
  • Ki Health PArtners LLC $144,469
  • Irvine Center for Clinical Research Inc $140,146
  • Las Vegas Medical Research LLC $137,552
  • Amo Corporation of Tallahassee $132,727
  • Emerald Coast Neurology $118,197
  • Visionary Investigators Network $110,376
  • University of Texas Health $109,283
  • Erg Holding Co LLC DBA St Louis Clinical Trials LLC $105,177
  • Jacksonville Center for Clinical Research $105,140
  • Indiana University $91,484
  • UCSF Langley Porter Psychiatric Hospital and Clinics, CA $89,267
  • Intercoastal Medical Group $86,544
  • National Clinical Research Inc $81,062
  • Clinical Neuroscience Solutions DBA Cns Hlthcare $77,799
  • Brainstorm Research $58,032
  • Profound Research LLC $54,236
  • Neurology Clinic PC $51,896
  • Yale University $51,072
  • Usc School of Medicine $50,139
  • Interspond LLC $47,727
  • Stephen R Waldman MD Phd Inc $46,796
  • Piedmont Medical Research Associates Inc $46,579
  • Valley Medical Research $46,575
  • The Ohio State University $42,860
  • Neurology Consultants of Dallas PA $40,972
  • Indago Research & Health Center Inc $39,609
  • Neurology Diagnostics Inc $38,091
  • Research Foundation of State Univ of Ny $38,003
  • Alpine Clinical Research Center Inc $36,823
  • Sharp Mesa Vista Hospital $36,255
  • Renstar Inc $36,247
  • Neurologlocal Associates of Albany PC $32,769
  • Erg Clinical Research New York PLLC DBA Richmond Behavioral Associates $32,723
  • Quantum Laboratories Inc $31,549
  • Mercyone Waterloo Medical Center, IA $30,937
  • Neuroscience Research Center LLC $30,864
  • Keystone Clin Studies $30,706
  • Neural Net Research LLC $30,400
  • Instituto De Neurologia Dra Ivonne Frag Psc $30,085
  • Univ of South Florida Rsrch Foundation $29,498
  • Ezy Medical Research Co $29,035
  • Alzheimer's Memory Center $28,407
  • Citizens Memorial Hospital District $27,863
  • Strong Memorial Hospital, NY $27,605
  • Aqualane Clinical Research LLC $27,544
  • Central State Research $25,582
  • Northwest Clinical Research Center $24,545
  • Adams Clinical Inc $23,699
  • Jem Headlands LLC $23,201
  • Medvadis Research Corp LLC $20,678
  • Sentara Norfolk General Hospital, VA $19,614
  • Headlands Eastern Ma LLC $18,720
  • Clinical Research Professionals LLC $18,224
  • Univ of Kansas Med Cntr Rsrch Institute $18,092
  • Advanced Memory Research Institute of Nj PC $17,837
  • Colorado Springs Neurological Associates $17,578
  • Univ of Tx Health Sciences Center at San Antonio $17,506
  • Quest Research Institute LLC $16,413
  • Axiom Brain Health LLC $16,028
  • Hoag Memorial Hospital Presbyterian $15,234
  • Premier Research Institute $14,685
  • Center for Advanced Research & Education LLC $14,586
  • Neuro PAin Medical Center Inc $14,230
  • Elligo Health Research Inc $13,510
  • Alison B Allen MD $13,351
  • Suncoast Clinical Research $11,827
  • Advocate Christ Hospital & Medical Center, IL $11,758
  • Napa Biomedical Services Inc DBA Neurovations $10,750
  • Institute for Neurodegenerative Disorders $10,657
  • Artemis Headlands LLC $10,538
  • King County Public Hospital $10,032
  • New York University $9,917
  • Clinical Research Advantage $9,544
  • Cotton Oneil Msd of Stormont Vail Healthcare $9,510
  • Josephson Wallack Munshower Neurology $9,180
  • Great Lakes Clinical Trials $9,133
  • Hospital of Univ of Pennsylvania, PA $8,871
  • Kingfisher Cooperative LLC $8,812
  • Thomas M Shiovitz MD Inc $8,693
  • Board of Trustees of the Leland Stanford Jr Univ $8,321
  • Mainehealth Maine Medical Center, ME $8,316
  • Universal Research Group LLC $8,126
  • Sharlin Health and Neurology LLC $8,111
  • Neurology Associates of Tucson $7,980
  • Precise Clinical Research Inc $7,203
  • Progressive Medical Concepts LLC $7,155
  • Mount Sinai Medical Center of Florida, Inc, FL $6,942
  • Stedman Clinical Trials $6,901
  • Inspira Mental Health Management Inc $6,765
  • $6,726
  • Senior Adult Specialty Research $6,699
  • Board of Trustees of Southern Illinois University $6,573
  • Velocity Clinical Research Inc $6,165

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.