An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
Terminated · Phase 2 · NCT04686786
Conditions: Seizures
At a glance
- Research payments reported, 2025
- $172,248
- U.S. investigators named
- 19
- Sites paid
- 21
- Planned or actual enrollment
- 105
About the trial
- Sponsor
- AbbVie
- Tested
- CVL-865 (drug)
- Dates
- Started 2020-12-08; completion 2024-12-05
- Results posted
- Yes
The purpose of this study is to assess the long-term safety and tolerability of CVL-865 as adjunctive therapy in participants with focal onset seizures.
From ClinicalTrials.gov, last updated 2025-12-11. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $172,248 in research payments for this study in 2025 (51 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Aline Herlopian Neurology · New Haven, CT
- Selim R. Benbadis, MD Neurology · Tampa, FL
- Weldon A. Mauney III, M.D. Child Neurology · Gulf Breeze, FL
- Bashar Mohsen, MD Neurology · Miami Lakes, FL
- Ahmed H. Sadek, M.D. Neurology · Orlando, FL
- William O. Tatum, DO Neurology · Jacksonville, FL
- Kore K. Liow, MD Neurology · Honolulu, HI
- Toufic A. Fakhoury, MD Neurology · Lexington, KY
- Andrew J. Cole, MD Neurology · Boston, MA
- Robert E. Hogan III, MD Neurology · Saint Louis, MO
- Daniel T. Mattson, MD Neurology · Bridgeton, MO
- Ruben I. Kuzniecky, M.D. Neurology · New York, NY
- Eric B. Segal, M.D. Child Neurology · N White Plains, NY
- Trenton J. Tollefson, M.D. Neurology · Rochester, NY
- Imran I. Ali, M.D. Neurology · Toledo, OH
- Veronique Sebastian, MD Psychiatry · Oklahoma City, OK
- Michael A. Gelfand, MD Neurology · Philadelphia, PA
- Zeke M. Campbell, M.D. Neurology · Charleston, SC
- Bassel Abou-khalil, MD Neurology · Nashville, TN
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Medical University of South Carolina $31,260
- University of Utah Hospital and Clinics, UT $21,015
- The Feinstein Institutes for Medical Research $19,974
- Hawaii PAcific Neuroscience LLC $14,470
- Vanderbilt University Medical Center, TN $8,900
- Yale University $8,548
- Hospital of Univ of Pennsylvania, PA $7,488
- Clinical Research Professionals LLC $7,318
- The Washington University $7,176
- The University of Toledo $7,145
- Research Institute of Orlando LLC $6,768
- The University of South Florida Board of Trustees $6,587
- Assertive Research Center LLC $4,608
- Massachusetts General Hospital, MA $3,675
- Sooner Clinical Research Inc $3,137
- Northwest Florida Clinical Research Group LLC $3,000
- Assertive Research Center Inc $2,853
- Bluegrass Epilepsy Research LLC $2,639
- Mayo Clinic Jacksonville $2,494
- Strong Memorial Hospital, NY $1,972
- Epilepsy and Neurophysiology Medical Consultants PA $1,218
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.