A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors
Active, not recruiting · Phase 1 · NCT04707248
Conditions: Renal Cell Carcinoma, Ovarian Tumor
At a glance
- Research payments reported, 2025
- $1.1M
- U.S. investigators named
- 32
- Sites paid
- 44
- Planned or actual enrollment
- 179
About the trial
- Sponsor
- Daiichi Sankyo (with Merck Sharp & Dohme LLC)
- Tested
- DS-6000a (drug), DS-6000a (drug)
- Dates
- Started 2020-12-22; completion 2026-12-30
- Results posted
- Not yet
This clinical trial will evaluate raludotatug deruxtecan (R-DXd; DS-6000a) in participants with advanced renal cell carcinoma (RCC) and ovarian cancer (OVC). The main goals of this study will be to investigate the recommended dose of R-DXd that can be given safely to participants, assess the adverse events of R-DXd, and evaluate the effectiveness of R-DXd.
From ClinicalTrials.gov, last updated 2026-09-04. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Daiichi Sankyo Inc. reported $1.1M in research payments for this study in 2025 (1,588 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Melissa M. Hardesty, MD Gynecologic Oncology · Anchorage, AK
- Joseph Buscema, M.D. Gynecologic Oncology · Tucson, AZ
- Manojkumar Bupathi, M.D. Hematology & Oncology · Littleton, CO
- Alessandro Santin, MD OB-GYN (Obstetrics & Gynecology) · New Haven, CT
- Gerardo Colon-otero, MD Hematology & Oncology · Jacksonville, FL
- Alexander Philipovskiy, M.D., PH.D Medical Oncology · Sanford, FL
- Matthew P. Schlumbrecht, MD Gynecologic Oncology · Miami, FL
- Brian M. Slomovitz, M.D. Gynecologic Oncology · Fort Lauderdale, FL
- Daniel W. Sonnenburg, M.D. Medical Oncology · Indianapolis, IN
- Katrina S. Wade, MD Gynecologic Oncology · New Orleans, LA
- Tashanna K. Myers, MD Gynecologic Oncology · Springfield, MA
- Premal H. Thaker, MD Gynecologic Oncology · Saint Louis, MO
- Angeles A. Secord, MD Gynecologic Oncology · Durham, NC
- Sharyn N. Lewin, M.D. Gynecologic Oncology · Teaneck, NJ
- Eleonora Teplinsky, M.D. Hematology & Oncology · Paramus, NJ
- Veena John Hematology & Oncology · Lake Success, NY
- Bhavana Pothuri, M.D. Gynecologic Oncology · New York, NY
- Rachel M. Bramblet, D.O. Gynecologic Oncology · Montgomery, OH
- Robert T. Neff, MD Gynecologic Oncology · Hilliard, OH
- David M. O'malley, M.D. Gynecologic Oncology · Hilliard, OH
- Peter G. Rose, MD Gynecologic Oncology · Cleveland, OH
- Michael A. Gold, MD Gynecologic Oncology · Tulsa, OK
- Debra L. Richardson, M.D. Gynecologic Oncology · Oklahoma City, OK
- Lainie P. Martin, M.D. Medical Oncology · Philadelphia, PA
- Brian C. Orr, MD Gynecologic Oncology · Charleston, SC
- Maria C. Bell, M.D. Gynecologic Oncology · Sioux Falls, SD
- Brian I. Rini, MD Hematology & Oncology · Nashville, TN
- Noelle G. Cloven, M.D. Gynecologic Oncology · Fort Worth, TX
- Shannon N. Westin, MD OB-GYN (Obstetrics & Gynecology) · Houston, TX
- Tarrik M. Zaid, MD Gynecologic Oncology · El Paso, TX
- Heidi J. Gray, MD Gynecologic Oncology · Seattle, WA
- Elizabeth E. Hopp, M.D. OB-GYN (Obstetrics & Gynecology) · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Arizona Oncology Associates $174,446
- Sarah Cannon Research Institute $96,060
- Ut MD Anderson Cancer Center $91,851
- Vanderbilt University Medical Center, TN $89,264
- Providence Alaska Medical Center, AK $78,557
- Hospital of Univ of Pennsylvania, PA $42,874
- Washington University $42,499
- St Elizabeth Edgewood, KY $40,349
- The Feinstein Institute for Medical Research $40,064
- Duke University $37,605
- Ou Health University of Oklahoma Medical Center $35,000
- Ohio State University $35,000
- Holy Name Medical Center $35,000
- The Valley Hospital $35,000
- University of Washington Medical Ctr, WA $35,000
- The Methodist Hospital Research Institute $35,000
- Sanford Gynecologic Oncology Clinic $28,062
- University of Miami $19,112
- Mount Sinai Medical Center of Florida, Inc, FL $9,312
- Rocky Mountain Cancer Centers $8,500
- New York University School of Medicine $6,153
- University of Miami Hospital $4,590
- Texas Oncology- Fort Worth Cancer Center $4,307
- Oklahoma Cancer Specialists and Research Institute $4,047
- Uhealth University of Miami Health System $3,840
- Northwell Health Zuckerberg Cancer Center $3,098
- NYU Langone Health Perlmutter Cancer Center $3,002
- Providence Cancer Center $2,597
- Musc Hollings Cancer Center $2,118
- Florida Cancer Specialists and Research Institute Lake Mary Cancer Center $1,928
- Duke University Hospital, NC $1,540
- Ou Health Stephenson Cancer Center $1,320
- Hackensack University Medical Center, NJ $1,216
- Baystate Medical Center, MA $1,000
- Cleveland Clinic, OH $931
- Fred Hutchinson Cancer Center $589
- Houston Methodist Hospital, TX $583
- Mayo Clinic, FL $583
- Froedtert Memorial Lutheran Hospital, WI $583
- Yale University $478
- Jamescare Gynecologic Oncology at Mill Run $463
- Community Hospital East, IN $405
- Ochsner Clinic Foundation $44
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.