Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis
Completed · Phase 3 · NCT04708782
Conditions: Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
At a glance
- Research payments reported, 2025
- $4.5M
- U.S. investigators named
- 93
- Sites paid
- 88
- Planned or actual enrollment
- 598
About the trial
- Sponsor
- United Therapeutics
- Tested
- Placebo (drug), Inhaled Treprostinil (drug), Treprostinil Ultrasonic Nebulizer (device)
- Dates
- Started 2021-06-01; completion 2026-02-02
- Results posted
- Not yet
Study RIN-PF-301 is designed to evaluate the superiority of inhaled treprostinil against placebo for the change in absolute forced vital capacity (FVC) from baseline to Week 52.
From ClinicalTrials.gov, last updated 2026-05-05. Full record, eligibility and contacts (opens in a new tab)
Industry funding
United Therapeutics Corporation reported $4.5M in research payments for this study in 2025 (1,575 payments).
Products named: Tyvaso
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Tejaswini Kulkarni Pulmonology · Birmingham, AL
- Shehabaldin Alqalyoobi, M.D. Critical Care Medicine · Scottsdale, AZ
- Sachin Chaudhary, MD General Acute Care Hospital · Tucson, AZ
- Rajat Walia, MD Pulmonology · Phoenix, AZ
- Ayad M. Gharghoury, M.D. Pulmonology · Yucca Valley, CA
- Jeffrey A. Golden, MD Pulmonology · San Francisco, CA
- Ryan M. Klein, MD Internal Medicine · Newport Beach, CA
- Rishi Raj, M.D. Critical Care Medicine · Stanford, CA
- Namita Sood, M.D. Pulmonology · Sacramento, CA
- Stephen S. Weigt, MD Pulmonology · Los Angeles, CA
- Bassam Yaghmour, M.D. Critical Care Medicine · Orange, CA
- Gordon L. Yung, M.D. Pulmonology · San Diego, CA
- Joshua J. Solomon, MD Pulmonology · Denver, CO
- Tunay Kuru, MD Critical Care Medicine · Washington, DC
- Sashi Adigopula, M.D. Heart Failure & Transplant Cardiology · Fort Myers, FL
- Ala T. Ahmad, M.D. Critical Care Medicine · St Petersburg, FL
- Francis J. Averill, MD Pulmonology · Clearwater, FL
- Debabrata Bandyopadhyay, MD Critical Care Medicine · Orlando, FL
- Harish Bhaskar, MD Pulmonology · Jacksonville, FL
- Ibrahim Faruqi, MD Critical Care Medicine · Gainesville, FL
- Augustine Lee, MD Pulmonology · Jacksonville, FL
- Jinesh Mehta, M.D. Pulmonology · Weston, FL
- Syed I. Mobin, M.D. Pulmonology · Orlando, FL
- Santosh M. Nair, MD Hematology & Oncology · Orange City, FL
- Vandana Seeram, M.D. Critical Care Medicine · Jacksonville, FL
- Neal Warshoff, D.O. Pulmonology · Loxahatchee, FL
- Amy H. Case, MD Pulmonology · Austell, GA
- Srihari Veeraraghavan, M.D. Pulmonology · Atlanta, GA
- Nishal Brahmbhatt, MD Critical Care Medicine · Honolulu, HI
- Bradford Bemiss, MD Pulmonology · Maywood, IL
- Jane Dematte Damico, MD Pulmonology · Chicago, IL
- Daniel Dilling, MD Critical Care Medicine · Maywood, IL
- Dustin R. Fraidenburg, M.D. Pulmonology · Chicago, IL
- Xiaoping Wu, M.D. Pulmonology · Chicago, IL
- Mark Yoder, M.D. Pulmonology · Chicago, IL
- Sahil M. Pandya, M.D. Pulmonology · Kansas City, KS
- John W. Mcconnell, M.D. Pulmonology · Louisville, KY
- Mohamed Saad, MD Pulmonology · Louisville, KY
- Sally A. Suliman, M.D Pulmonology · Louisville, KY
- Afsana Asharaf, MD Pulmonology · Shreveport, LA
- Amita Krishnan, M.D. Pulmonology · New Orleans, LA
- Joseph Lasky, MD Pulmonology · New Orleans, LA
- Gautam George, M.D. Pulmonology · Cambridge, MA
- Leo C. Ginns, MD Pulmonology · Boston, MA
- Nicholas S. Hill, MD Pulmonology · Boston, MA
- Gary M. Hunninghake, MD Pulmonology · Boston, MA
- Jonathan B. Cohen, M.D. Internal Medicine · Rockville, MD
- Sonye K. Danoff, M.D. Pulmonology · Baltimore, MD
- Elizabeth A. Belloli, M.D. Pulmonology · Ann Arbor, MI
- Krishna Thavarajah, M.D. Pulmonology · Detroit, MI
- Hyun Joo Kim, MD Pulmonology · Minneapolis, MN
- Teng Moua, M.D. Pulmonology · Rochester, MN
- Neil Ettinger, MD Pulmonology · Chesterfield, MO
- Tonya D. Russell, MD Pulmonology · Saint Louis, MO
- Mark B. Yagan, M.D. Pulmonology · Kansas City, MO
- Andrew M. Wilhelm, D.O. Pulmonology · Jackson, MS
- Benjamin J. Bregman, M.D. Critical Care Medicine · Winston Salem, NC
- Murali Ramaswamy, MD FAAFP Pulmonology · Greensboro, NC
- Lee Morrow, M.D. Pulmonology · Omaha, NE
- Nour A. Ass'ad, M.D. Internal Medicine · Albuquerque, NM
- Alpa G. Desai, M.D. Pulmonology · Stony Brook, NY
- Sherif G. El Bayadi, MD Pulmonology · Syracuse, NY
- Robert M. Kottmann, M.D. Pulmonology · Rochester, NY
- Ali Mansour, MD Internal Medicine · Bronx, NY
- Arunabh Talwar, MD Pulmonology · New Hyde Park, NY
- Nitin Y. Bhatt, MD Pulmonology · Columbus, OH
- Nishant Gupta, M.D. Pulmonology · Cincinnati, OH
- Joseph G. Parambil, M.D. Pulmonology · Cleveland, OH
- Jad Kebbe, M.D. Pulmonology · Oklahoma City, OK
- Granthem T. Farr, DO Pulmonology · Portland, OR
- Michaela R. Anderson, M.D. Pulmonology · Philadelphia, PA
- Rebecca Bascom, M.D. Pulmonology · Hershey, PA
- Parth M. Rali, MD Pulmonology · Philadelphia, PA
- Michael B. Denenberg, M.D. Pulmonology · Rock Hill, SC
- Abhinav Gupta, M.D. Critical Care Medicine · Columbia, SC
- Rachana Krishna, M.D. Pulmonology · Charleston, SC
- Justin C. Hewlett, MD Pulmonology · Nashville, TN
- Aaron Milstone, MD Pulmonology · Franklin, TN
- Eric M. Weaver, MD Pulmonology · Knoxville, TN
- Traci N. Adams, MD Pulmonology · Dallas, TX
- Alfredo R. Arauco Brown, M.D. Pulmonology · Weslaco, TX
- Rahat Hussain, MD Internal Medicine · Houston, TX
- Shahrukh A. Kureishy, MD Pulmonology · Mckinney, TX
- Ivan O. Rosas, M.D. Pulmonology · Houston, TX
- Yosafe Wakwaya, M.D. Pulmonology · Dallas, TX
- Peter F. Crossno, MD Critical Care Medicine · Murray, UT
- Mary B. Scholand, MD Pulmonology · Salt Lake City, UT
- Anne W. Brown, M.D. Pulmonology · Falls Church, VA
- Shilpa Johri, MD Pulmonology · Richmond, VA
- Christopher S. King, MD Critical Care Medicine · Falls Church, VA
- Hannah C. Mannem, M.D. Pulmonology · Charlottesville, VA
- Mark Barash, D.O. Pulmonology · Milwaukee, WI
- Stephen J. Halliday, M.D., MSCI Pulmonology · Madison, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Inova Loudoun Hospital, VA $199,168
- The University of Arizona $151,151
- Massachusetts General Hospital, MA $150,755
- Biomedical Research Alliance of New York LLC $141,833
- St Joseph's Medical PC $126,705
- The Washington University $113,707
- University of Michigan Health System, MI $113,402
- The Administrators of the Tulane Educational Fund $99,359
- Pulmonix, LLC $91,444
- A and A Research Consultants LLC $84,788
- The University of South Florida $84,400
- University of California Davis Medical Center, CA $82,751
- The Board of Trustees of the Leland Stanford Junior University $81,493
- Beaumont Hospital - Grosse Pointe, MI $80,241
- University of Wisconsin and Visual Sciences $78,508
- National Jewish Health, CO $69,404
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $66,214
- Ronald Reagan UCLA Medical Center, CA $64,283
- University of Cincinnati Physicians Company, LLC $64,102
- Brigham and Women's Hospital, MA $63,240
- Medical University of South Carolina $61,004
- Intermountain Health Utah Valley Hospital, UT $60,318
- University of Florida $60,033
- Baylor Research Institute $59,232
- University of Virginia Medical Center, VA $58,991
- The University of Texas Southwestern Medical Center $58,891
- Prisma Health Richland Hospital, SC $57,696
- University of Oklahoma $55,485
- Cleveland Clinic, OH $55,227
- Pulmonary Assoc of Richmond Inc $54,837
- Southeastern Research Center LLC $54,456
- Hospital of Univ of Pennsylvania, PA $53,046
- Metroplex Pulmonary and Sleep Center $52,682
- Newportnativemd Inc $50,120
- Cleveland Clinic Florida $49,970
- The Research Foundation Suny $49,082
- The Lung Research Center LLC $47,685
- Kumc Research Institute Inc $46,077
- The University of Texas Health $46,017
- Northwestern University $45,345
- The Johns Hopkins University $44,545
- Medical College of Wisconsin Inc $44,511
- Baylor College of Medicine $43,189
- Elligo Health Research Inc $41,754
- Mayo Clinic Jacksonville $41,691
- The Regents of the University of California $41,195
- Temple University of the Commonwealth System of Higher Education $40,616
- Center for Biomedical Research $40,324
- Thomas Jefferson University $39,916
- Clinical Research of Rock Hill $39,646
- $39,375
- University of Alabama Hospital, AL $39,375
- The Ohio State University $39,201
- University of Utah Hospital and Clinics, UT $38,450
- Adventist Healthcare Inc $37,386
- Uci Health-Orange, CA $36,133
- Piedmont Healthcare, Inc. $35,654
- Pennsylvania State University $34,781
- The Oregon Clinic PC $33,619
- Loyola University of Chicago $33,591
- East Carolina University $33,511
- St Josephs Hospital and Medical Center, AZ $33,096
- Henry Ford Health Hospital, MI $32,373
- Emory University Hospital, GA $32,364
- Regents of the University of Minnesota $30,077
- Community Hospital East, IN $30,061
- Central Florida Pulmonary Group P A $29,365
- Vanderbilt University Medical Center, TN $29,316
- University of New Mexico Hsc $29,300
- Mayo Clinic $26,932
- Clinical Trials Center of Middle Tennessee $26,527
- Coastal Medical Research Institute $26,126
- Tufts Medical Center, MA $25,975
- Strong Memorial Hospital, NY $25,870
- St Lukes Hospital of Kansas City, MO $25,606
- Louisiana State University Health $24,937
- Norton Healthcare Inc $24,934
- St Francis Holdings LLC $24,702
- Georgetown University $24,456
- Creighton University $21,766
- University of Mississippi Med Center, MS $19,450
- Louisiana State University Health Sciences Center $19,230
- The Queens Medical Center, HI $14,527
- Rush University Medical Center, IL $12,984
- University of Illinois Hospital and Clinics, IL $11,987
- University of Louisville Research Foundation Inc $10,064
- Lakeland Regional Health Systems Inc. $9,608
- Advanced Pulmonary Research Institu $9,596
- St Vincents Health System Inc $9,088
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.