Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks
Completed · Phase 3 · NCT04739059
Conditions: Hereditary Angioedema
At a glance
- Research payments reported, 2025
- $233,422
- U.S. investigators named
- 9
- Sites paid
- 9
- Planned or actual enrollment
- 171
About the trial
- Sponsor
- CSL Behring
- Tested
- CSL312 (biological)
- Dates
- Started 2021-03-29; completion 2025-11-21
- Results posted
- Yes
This phase 3b study will evaluate long-term safety and efficacy of CSL312 (also known as garadacimab) when administered subcutaneously (SC)
From ClinicalTrials.gov, last updated 2026-06-02. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Csl Behring reported $233,422 in research payments for this study in 2025 (111 payments).
Products named: Berinert, Andembry
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- John T. Anderson, M.D. Allergy & Immunology · Homewood, AL
- Karl V. Sitz, M.D. Allergy & Immunology · Little Rock, AR
- Connie Hsu, MD Allergy & Immunology · Litchfield Park, AZ
- Michael E. Manning, MD Allergy & Immunology · Scottsdale, AZ
- Joshua S. Jacobs, MD Allergy & Immunology · Walnut Creek, CA
- Huamin H. Li, MD, PHD Allergy & Immunology · Wheaton, MD
- Jonathan A. Bernstein, MD Allergy & Immunology · Cincinnati, OH
- Timothy J. Craig, DO Allergy & Immunology · Hershey, PA
- William R. Lumry, M.D. Specialist · Dallas, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Allergy and Asthma Clinical Research $102,632
- $27,456
- Research Solutions of Arizona (dcrpi) $26,535
- Bernstein Clinical Research Center $24,950
- Penn State State College of Medicine $18,660
- Institute for Asthma and Allergy $17,391
- Clinical Research Center of Alabama Homewood Office $12,012
- Acuro Research Inc $2,829
- Aara Research Center $695
- Allergy Asthma and Immunology Associates South Scottsdale Office $261
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.