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Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)

Completed · Phase 3 · NCT04751487

Conditions: Chronic Obstructive Pulmonary Disease

At a glance

Research payments reported, 2025
$1.4M
U.S. investigators named
59
Sites paid
50
Planned or actual enrollment
1,234

About the trial

Sponsor
Sanofi (with Regeneron Pharmaceuticals)
Tested
Itepekimab SAR440340 (drug), Placebo (drug)
Dates
Started 2021-02-12; completion 2025-08-28
Results posted
Yes

Primary Objective: Primary population (former smokers cohort): \- Evaluate the efficacy of itepekimab compared with placebo on the annualized rate of acute moderate-or-severe COPD exacerbations in former smokers with moderate-to-severe COPD Secondary Objectives: Primary population (former smokers cohort): * Evaluate the efficacy of itepekimab compared with placebo on pulmonary function in former smokers with moderate-to-severe COPD * Evaluate the efficacy of itepekimab compared with placebo on occurrence of acute exacerbation of COPD (AECOPD) in former smokers with moderate-to-severe COPD * Evaluate the efficacy of itepekimab compared with placebo on severe AECOPD in former smokers with m…

From ClinicalTrials.gov, last updated 2026-10-09. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Sanofi US Services Inc. reported $1.4M in research payments for this study in 2025 (221 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Care Access Research Llc $416,983
  • Pines Care Research Center Llc $92,960
  • Beautiful Minds Medical Center Llc $80,266
  • Elligo Health Research Inc $76,196
  • Direct Helpers Medical Center Inc Direct Helpers Research Center $56,408
  • Finlay Medical Research Corp $55,468
  • Johns Hopkins University $53,924
  • Interspond LLC $53,731
  • Allegheny Singer Research Institute $44,421
  • Allianz Research Institute Co Llc $42,054
  • My Community Research Center Inc $30,825
  • University of Cincinnati $28,912
  • UCSF Langley Porter Psychiatric Hospital and Clinics, CA $24,701
  • Lfros Research Llc $21,706
  • Kaushlendra Tripathi Medtrial Llc $19,814
  • Medster Research Llc $17,020
  • Newyorkpresbyterian Queens $16,998
  • Omega Research Debary Llc $14,375
  • Advanced Pulmonary Research Institute $12,580
  • Genesis Clinical Research $12,425
  • Innovation Medical Research Center, Inc $11,770
  • North Florida Found for Research Education $11,075
  • Innovative Research of West Florida $9,882
  • St Lukes Hospital, PA $9,600
  • Osf Heart of Mary Medical Center, IL $9,408
  • Temple University of the Commonwealth System of Higher Education $9,348
  • Ok Clinical Research LLC $9,080
  • Sun Research Inst LLC $8,625
  • American Health Research LLC $8,400
  • Palmtree Clinical Research Inc $8,200
  • Oviedo Medical Research $7,930
  • Cotton Oneil Clinic Revocable Trust Cotton Oneil Clinical Research Center $7,732
  • Sarasota Memorial Hospital, FL $7,200
  • Clinical Research of West Florida $7,000
  • Gmg Clinical Research Llc Radiance Clinical Research $6,579
  • Renstar Llc Renstar Medical Research $6,450
  • Buffalo Institute for Medical Research Inc $5,669
  • Science Connections Llc $5,518
  • Columbus Clinical Services $5,412
  • Kaiser Foundation Hospital-Santa Clara, CA $4,850
  • Innovo Research Inc $4,770
  • Helix Biomedics Llc $4,750
  • Wr Msra Llc $4,750
  • Rutgers State University $4,650
  • Adventhealth Medical Group Pulmonology at Orlando Ridgewood $4,320
  • Brcr Medical Center Inc $2,600
  • Lexington Biomedical Research Institute $2,500
  • Qcare Site Services Inc $1,200
  • Sierra Clinical Research $620
  • Puerto Rico Consortium for Clinical Investigation $500

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.