Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
Active, not recruiting · Phase 4 · NCT04790370
Conditions: Pulmonary Embolism
At a glance
- Research payments reported, 2025
- $391,403
- U.S. investigators named
- 27
- Sites paid
- 27
- Planned or actual enrollment
- 544
About the trial
- Sponsor
- Boston Scientific Corporation (with National PERT Consortium, Inc., University Medical Center Mainz)
- Tested
- Anticoagulation with heparin (drug), EkoSonicTM Endovascular System (device)
- Dates
- Started 2021-08-02; completion 2026-08
- Results posted
- Not yet
There are many available treatments for pulmonary embolism (PE), but the best treatment for this condition is not known. The HI-PEITHO study will compare two treatment options that are both available on the market for the treatment of PE. Patients will be randomized 1:1 to receive either blood thinners (anticoagulation) or blood thinners (anticoagulation) in combination with a device called the EkoSonicTM Endovascular device to dissolve blood clots. Patients will be followed for 12 months after randomization and have assessments while in the hospital as well as at 7 days, 30 days, 6 months and 12 months after randomization. The study will try to find out if one of these treatments is bett…
From ClinicalTrials.gov, last updated 2026-07-01. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Boston Scientific Corporation reported $391,403 in research payments for this study in 2025 (165 payments).
Products named: Clinical Trial Product
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Samuel Mcelwee Critical Care Medicine · Birmingham, AL
- Oren Friedman, MD Pulmonology · West Hollywood, CA
- Daniel A. Leung, M.D. Interventional Radiology · Newark, DE
- Vishal Arora, M.D. Interventional Cardiology · Augusta, GA
- William B. Keeling, MD Cardiothoracic Surgery · Atlanta, GA
- Andrew J. Klein, MD Interventional Cardiology · Atlanta, GA
- Mahesh N. Raju, MD Cardiology · Downers Grove, IL
- Mihas M. Kodenchery, MD Cardiology · Merrillville, IN
- Christopher A. Semder, MD Interventional Cardiology · Louisville, KY
- Shahab A. Toursavadkohi, M.D. Vascular Surgery · Baltimore, MD
- Geoffrey D. Barnes, M.D. Cardiology · Northville, MI
- Gerald Koenig, M.D. Cardiology · Detroit, MI
- Arashk Motiei, MD Cardiology · Rochester, MN
- Yue Gao, M.D. Vascular Surgery · Omaha, NE
- Michael N. Young, M.D. Cardiology · Lebanon, NH
- Elias A. Iliadis, MD Cardiology · Voorhees, NJ
- Gautam K. Visveswaran, M.D. Interventional Cardiology · Newark, NJ
- Bushra Mina, M.D. Pulmonology · New York, NY
- Sanjum S. Sethi, MD Interventional Cardiology · New York, NY
- Dan Shilo, M.D. Interventional Radiology · New York, NY
- Ammar Safar, MD Cardiology · Miamisburg, OH
- Marc W. Mayhew, MD Interventional Cardiology · Kingsport, TN
- Rahul Sakhuja, MD Interventional Cardiology · Kingsport, TN
- Peter P. Monteleone, MD Interventional Cardiology · Kyle, TX
- Uttam Tripathy, MD Cardiothoracic Surgery · Sugar Land, TX
- John F. Angle, MD Interventional Radiology · Charlottesville, VA
- Kurt M. Jacobson, M.D. Interventional Cardiology · Madison, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Dartmouth Hitchcock Clinic $124,448
- Methodist Hospitals Inc, IN $51,709
- Massachusetts General Hospital, MA $36,488
- Mayo Clinic $19,000
- University of Alabama Hospital, AL $16,844
- Board of Regents of the University of Wisconsin System $14,431
- Christiana Hospital, DE $12,939
- University of Virginia Medical Center, VA $12,037
- Newark Beth Israel Medical Center, NJ $11,639
- Augusta University Research Institute Inc $11,472
- Trustees of Columbia Univ in The City of Ny $10,441
- Cooper University Hospital, NJ $10,000
- Ascension Seton Medical Center Austin $9,931
- University of Michigan Medical Center $9,184
- Henry Ford Health Hospital, MI $6,893
- Cedars-Sinai Medical Center, CA $6,231
- Physicians Clinic Inc. $5,208
- Kettering Health Main Campus, OH $4,680
- University of Maryland $3,610
- Piedmont Healthcare $3,185
- Baptist Health Lexington, KY $2,252
- Wellmont Cardiology Services $1,950
- The Methodist Hospital Research Institute $1,826
- Emory University Hospital, GA $1,672
- Icahn School of Medicine at Mount Sinai $1,305
- Biomedical Research Alliance of New York $1,299
- Aurora Research Institute LLC $729
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.