A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Recruiting · Phase 3 · NCT04844606
Conditions: Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
At a glance
- Research payments reported, 2025
- $439,459
- U.S. investigators named
- 8
- Sites paid
- 10
- Planned or actual enrollment
- 150
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Mirikizumab (drug), Mirikizumab (drug)
- Dates
- Started 2021-05-26; completion 2030-12
- Results posted
- Not yet
The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits. Additional treatment may be available to participants via a Continued Access Period.
From ClinicalTrials.gov, last updated 2026-10-07. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $439,459 in research payments for this study in 2025 (16 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Sofia G. Verstraete, M.D. Student in an Organized Health Care Education/Training Program · San Francisco, CA
- Jeffrey S. Hyams, MD Pediatric Gastroenterology · Hartford, CT
- Subra Kugathasan, MD Pediatric Gastroenterology · Atlanta, GA
- Jeffery D. Lewis, MD Pediatric Gastroenterology · Atlanta, GA
- Athos Bousvaros, MD, MPH Pediatric Gastroenterology · Boston, MA
- Jess L. Kaplan, MD Pediatrics · Boston, MA
- David S. Dunkin, M.D. Pediatric Gastroenterology · New York, NY
- Clifton S. Huang, MD Pediatric Gastroenterology · Fort Worth, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $134,803
- Massachusetts General Hospital, MA $96,022
- Childrens Center for Digestive Health Care LLC $54,527
- Boston Children's Hospital, MA $46,937
- Mount Sinai School of Medicine $34,297
- Cook Childrens Medical Center, TX $31,869
- Childrens Healthcare of Atlanta $24,433
- Connecticut Childrens Medical Center, CT $14,756
- Emory University Hospital, GA $1,738
- Ronald Reagan UCLA Medical Center, CA $77
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.