A Phase 1 Study to Investigate the Safety and Pharmacokinetics of Fosigotifator in Patients With Amyotrophic Lateral Sclerosis
Terminated · Phase 1 · NCT04948645
Conditions: ALS, Amyotrophic Lateral Sclerosis
At a glance
- Research payments reported, 2025
- $220,932
- U.S. investigators named
- 7
- Sites paid
- 9
- Planned or actual enrollment
- 31
About the trial
- Sponsor
- AbbVie (with Calico Life Sciences LLC)
- Tested
- Fosigotifator (drug), Placebo (drug)
- Dates
- Started 2021-09-22; completion 2025-07-15
- Results posted
- Not yet
Fosigotifator is an investigational drug being researched for the treatment of Amyotrophic Lateral Sclerosis. This is an up to 156-week, 2-part study. Part 1 will be a 4-week, randomized, double-blind, placebo-controlled study; Part 2 will be up to a 152-week active treatment extension (ATE) during which all subjects will receive Fosigotifator.
From ClinicalTrials.gov, last updated 2025-08-01. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $220,932 in research payments for this study in 2025 (38 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Frank Diaz, M.D., PH.D. Neurology · West Hollywood, CA
- Namita Goyal, M.D. Physical Medicine & Rehabilitation (PM&R) · Orange, CA
- Jonathan Katz, M.D. Neurology · San Francisco, CA
- Bjorn Oskarsson, MD Neurology · Jacksonville, FL
- Doreen T. Ho, MD Neurology · Burlington, MA
- Nicholas Maragakis, M.D. Neurology · Baltimore, MD
- Nathan P. Staff, M.D. Neurology · Rochester, MN
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- The Johns Hopkins University $46,169
- Mayo Clinic - Rochester $38,735
- Massachusetts General Hospital, MA $33,768
- California PAcific Medical Center- Van Ness Campus, CA $29,143
- Mayo Clinic Jacksonville $23,127
- Johns Hopkins University $18,296
- Uci Health - Fountain Valley, CA $14,646
- Cedars-Sinai Medical Center, CA $8,580
- Uci Health-Orange, CA $6,468
- $2,000
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.