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A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)

Active, not recruiting · Phase 3 · NCT04951219

Conditions: Non-Alcoholic Fatty Liver Disease

At a glance

Research payments reported, 2025
$17.5M
U.S. investigators named
144
Sites paid
139
Planned or actual enrollment
810

About the trial

Sponsor
Madrigal Pharmaceuticals, Inc.
Tested
Resmetirom (drug)
Dates
Started 2021-07-09; completion 2027-04
Results posted
Not yet

A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)

From ClinicalTrials.gov, last updated 2026-05-27. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Madrigal Pharmaceuticals reported $17.5M in research payments for this study in 2025 (3,121 payments).

Products named: Rezdiffra

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • The Institute for Liver Health II LLC $1.6M
  • Pinnacle Clinical Research PLLC $914,503
  • Delta Research PArtners of Bastrop LLC $635,081
  • Houston Research Institute LLC $616,404
  • Bon Secours Mercy Health Inc $608,613
  • Kansas City Research Institute LLC $527,416
  • South Texas Research Institute $511,582
  • Arizona Liver Health $463,213
  • Delta Research PArtners LLC $412,399
  • Duke University $398,003
  • Covenant Metabolic Specialists LLC $375,419
  • Velocity Clinical Research Inc $349,985
  • Mayo Clinic $346,160
  • Adobe Clinical Research LLC $324,696
  • Texas Digestive Disease Consultants PLLC $319,917
  • California Liver Research Institute $303,490
  • Louisiana Research Center LLC $294,594
  • South Denver Gastroenterology PC $266,556
  • Liver Center of Texas PLLC $243,341
  • UCSF Langley Porter Psychiatric Hospital and Clinics, CA $227,102
  • Gastroenterology Center of the Midsouth PLLC $196,053
  • Jacksonville Center for Clinical Research $189,416
  • Northwestern University $189,258
  • Boston Medical Center, MA $188,779
  • Gastro One $187,332
  • Arkansas Gastroenterology PA $186,016
  • Methodist Dallas Medical Center, TX $182,784
  • University of Pittsburgh Physicians $182,095
  • Florida Digestive Health Specialists LLP $171,022
  • Pinnacle Clinical Research LLC $165,060
  • Fundacion De Investigacion De Diego Inc $163,503
  • University of Southern California $161,888
  • Gastrointestinal Specialists of Georgia PC $155,863
  • Apex Mobile Clinical Research LLC $152,309
  • Medical University of South Carolina $149,028
  • Baylor College of Medicine $145,933
  • Gastroenterology Center of the Midsouth PLLC $144,023
  • International Center for Research $143,972
  • Virginia Commonwealth University $136,614
  • Tampa Bay Medical Research Inc $135,115
  • Kansas Medical Clinic PA $125,401
  • Thomas Jefferson University $113,998
  • Lucas Research Inc $111,068
  • Ocala Gi Research LLC $105,361
  • Fdi Clinical Research $102,800
  • Summit Clinical Research LLC $97,316
  • Dhr Health Institute for R&d $95,945
  • Texas Clinical Research Institute LLC $95,636
  • Wake Forest University Health Sciences $95,581
  • International Center for Research LLC $95,020
  • University of Texas Southwestern Medical Center $91,578
  • Dallas VA Research Corporation $91,453
  • Knowledge Research Center $87,642
  • Digestive Research of Central Texas LLC $87,083
  • St Louis University $85,963
  • Hi Tech and Global Research LLC $84,346
  • Aes Orlando $84,149
  • Richmond Institute for Veterans Research $83,655
  • Weill Medical College of Cornell University $82,858
  • The Methodist Hospital Research Institute $82,559
  • University of Kansas Medical Center Research Institute Inc $79,895
  • Usdh Clinical Research LLC $77,872
  • Crioh LLC $76,397
  • Rush University Medical Center, IL $75,416
  • Beth Israel Deaconess Medical Center, MA $75,272
  • Saint PAul Place Specialists Inc $73,688
  • The Ohio State University $70,920
  • Tandem Clinical Research Gi LLC $70,458
  • Adventhealth Orlando, FL $68,890
  • St PAul Place Specialists Inc $66,892
  • Latin Clinical Trial Center Inc $64,590
  • Rapid City Medical Center LLP $64,166
  • Mount Sinai School of Medicine $63,685
  • Clinical Research Institute of Ohio LLC $61,794
  • Floridian Clinical Research LLC $61,233
  • Coastal Research Institute LLC $56,072
  • The Administrators of the Tulane Educational Fund $53,996
  • University of Virginia Medical Center, VA $53,430
  • Aes the Villages $52,899
  • Liver Center of Texas $51,263
  • Colombia Digestive Health Research LLC $48,795
  • Aes Salt Lake City $48,067
  • Knowlege Research Center $47,613
  • University of Miami $46,906
  • California Liver Research Center $46,034
  • Bon Secours-Richmond Community Hospital Incorporated $43,811
  • Quality Medical Research PLLC $42,587
  • University of Massachusetts $37,621
  • Jacksonville Center for Clinical Research LTD $36,835
  • Arkansas Gastroenterology $36,728
  • University of Florida $34,665
  • New York University School of Medicine $33,551
  • Gi Select Health Research LLC $33,075
  • Excel Medical Clinical Trials LLC $32,969
  • Univ. of Vermont - Fletcher Allen Health Care, VT $32,802
  • Gastrointestinal Specialists of Georgia $30,880
  • Premier Medical Group PC $29,725
  • University of Washington Medical Ctr, WA $29,481
  • Aes San Antonio $29,195
  • Aes Henderson $27,682

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.