Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
Active, not recruiting · Phase 3 · NCT04988386
Conditions: Amyloid Cardiomyopathy, Transthyretin-Related
At a glance
- Research payments reported, 2025
- $337,921
- U.S. investigators named
- 26
- Sites paid
- 26
- Planned or actual enrollment
- 389
About the trial
- Sponsor
- Eidos Therapeutics, a BridgeBio company
- Tested
- Acoramidis (AG10) (drug)
- Dates
- Started 2021-10-27; completion 2028-05-15
- Results posted
- Not yet
Open-Label Extension and Safety Monitoring Study of Acoramidis (AG10) in Participants with Symptomatic Transthyretin Amyloid Cardiomyopathy Who Completed the Phase 3 ATTRibute-CM Trial (AG10-301)
From ClinicalTrials.gov, last updated 2025-10-14. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eidos Therapeutics, Inc. reported $337,921 in research payments for this study in 2025 (134 payments).
Products named: Attruby
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- David H. Chang, MD Heart Failure & Transplant Cardiology · Beverly Hills, CA
- Amrut V. Ambardekar, MD Heart Failure & Transplant Cardiology · Aurora, CO
- Nitasha Sarswat, MD Heart Failure & Transplant Cardiology · Chicago, IL
- Sanjiv Shah, MD Cardiology · Chicago, IL
- John L. Berk, M.D. Pulmonology · Boston, MA
- Sandeep M. Jani, MD, MPH Heart Failure & Transplant Cardiology · Baltimore, MD
- Martha Grogan, M.D. Cardiology · Rochester, MN
- Joshua D. Mitchell, MD Cardiology · Saint Louis, MO
- Brett W. Sperry, MD Heart Failure & Transplant Cardiology · Kansas City, MO
- Michel G. Khouri, M.D. Cardiology · Durham, NC
- Olakunle O. Akinboboye, MD MPH Internal Medicine · Laurelton, NY
- Mathew S. Maurer, M.D. Heart Failure & Transplant Cardiology · New York, NY
- Alex Reyentovich, M.D. Heart Failure & Transplant Cardiology · New York, NY
- James M. Tauras, MD Internal Medicine · Bronx, NY
- Mazen A. Hanna, M.D. Cardiology · Cleveland, OH
- Ahmad M. Masri, M.D Cardiology · Portland, OR
- Brian M. Drachman, MD Cardiology · Philadelphia, PA
- Prem Soman Nuclear Medicine · Pittsburgh, PA
- Daniel P. Judge, M.D. Heart Failure & Transplant Cardiology · Charleston, SC
- Justin L. Grodin, MD Heart Failure & Transplant Cardiology · Dallas, TX
- Josef Stehlik, MD Heart Failure & Transplant Cardiology · Salt Lake City, UT
- Mirnela P. Byku, MD Heart Failure & Transplant Cardiology · Charlottesville, VA
- John F. Schmedtje JR., M.D. Cardiology · Roanoke, VA
- Keyur B. Shah, MD Heart Failure & Transplant Cardiology · Richmond,, VA
- Richard K. Cheng, M.D. Heart Failure & Transplant Cardiology · Seattle, WA
- Deirdre M. Mooney, MD, MPH Heart Failure & Transplant Cardiology · Spokane, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Mayo clinic $45,543
- Virginia Commonwealth University School of Medicine $28,444
- University of Pittsburgh Physicians $25,431
- Northshore University Healthsystem - Evanston Hospital, IL $24,728
- University of Utah Hospital and Clinics, UT $22,205
- The Trustees of Columbia University in The City of New York $21,171
- St Lukes Hospital of Kansas City, MO $18,925
- Duke University $17,482
- Biomedical Research Alliance of New York LLC $17,186
- Cedars-Sinai Medical Center, CA $15,571
- University of Washington Medical Ctr, WA $13,330
- Medical University of South Carolina $12,672
- Medstar Research Institute $10,038
- University of Colorado Denver School of Medicine $9,094
- Prov Sacred Hrt Med Ctr & Childs Hosp., WA $8,281
- Roanoke Heart Institute PLC $6,737
- The University of Texas Southwestern Medical Center $6,376
- Hospital of Univ of Pennsylvania, PA $6,324
- Northwestern University $6,290
- Washington University $6,124
- New York University School of Medicine $5,381
- Cleveland Clinic, OH $3,883
- Ohsu Hospital and Clinics, OR $2,586
- Laurelton Heart Specialist PC $2,200
- University of Chicago $1,560
- Boston University School of Medicine $358
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.