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A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)

Active, not recruiting · Phase 3 · NCT05026866

Conditions: Alzheimer Disease

At a glance

Research payments reported, 2025
$41.2M
U.S. investigators named
150
Sites paid
110
Planned or actual enrollment
2,996

About the trial

Sponsor
Eli Lilly and Company
Tested
Donanemab (drug), Placebo (drug)
Dates
Started 2021-08-27; completion 2027-11
Results posted
Not yet

The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD) over up to 332 weeks. Approximately 800 additional participants will be enrolled in the 12-month Addendum 7 to assess safety of a different titration regimen.

From ClinicalTrials.gov, last updated 2026-01-21. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $41.2M in research payments for this study in 2025 (290 payments).

Products named: Kisunla

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Progressive Medical Concepts LLC $4.0M
  • Charter Research LLC $3.8M
  • Care Access Research LLC $3.4M
  • K2 Medical Research LLC $3.1M
  • Las Vegas Medical Research LLC $2.7M
  • Irvine Center for Clinical Research Inc $2.2M
  • Medvadis Research Corp LLC $1.6M
  • Conquest Research LLC $1.3M
  • Artemis Headlands LLC $1.3M
  • Revival Research Institute LLC $1.2M
  • Great Lakes Clinical Trials $1.1M
  • Indago Research & Health Center Inc $970,702
  • Cenexel Iresearch LLC $870,490
  • Northwest Clinical Trials Inc $765,587
  • Monroe Biomedical Research $702,497
  • Clinical Trials Research Inc $670,500
  • North Georgia Clinical Research $669,790
  • Elligo Health Research Inc $651,859
  • Headlands Horizons LLC $599,275
  • Northwest Clinical Research Center $589,068
  • Emerald Coast Neurology $555,065
  • Tandem Intermediate LLC $548,651
  • Bradenton Research Center Inc $501,525
  • Center for Advanced Research & Education LLC $460,321
  • Visionary Investigators Network $428,350
  • Merritt Island Medical Research LLC $405,707
  • Finlay Medical Research Corp $375,604
  • Universal Research Group LLC $373,635
  • St Jude Heritage Healthcare $370,764
  • Lightship Inc $352,694
  • Velocity Clinical Research Inc $341,336
  • Jacksonville Center for Clinical Research $319,352
  • Suncoast Clinical Research $319,257
  • University of Texas Health $315,183
  • Raa Apex Acquisition LLC $311,702
  • Citizens Memorial Hospital District $304,155
  • Healix Infusion Therapy LLC $292,457
  • Scb Research Center Corp $253,570
  • Josephson Wallack Munshower Neurology $207,974
  • Gadolin Research LLC $172,516
  • $166,404
  • Senior Adult Specialty Research $161,689
  • Ima Evaluations LLC DBA Ima Clinical Research $155,808
  • Stedman Clinical Trials $138,773
  • Neurology Diagnostics Inc $115,566
  • Consano Clinical Research LLC $114,655
  • Mercyone Waterloo Medical Center, IA $92,131
  • Napa Biomedical Services Inc DBA Neurovations $85,455
  • M Super Holdings LLC Ima Evaluations LLC $80,119
  • Tilda Research Inc $70,970
  • Nluc PLLC $60,769
  • Piedmont Medical Research Associates Inc $59,377
  • Invicro $55,941
  • Excel Medical Clinical Trials, LLC $54,962
  • Prime Global Research Inc $44,013
  • Norton Healthcare Inc $43,457
  • Radiant Skin and Health LLC DBA Conroe Willis Medical Research $32,638
  • Clinical Research of West Florida Inc $26,919
  • Carteret Medical Group LLC $26,742
  • Valley Clinical Trials Inc $21,563
  • Alison B Allen MD $21,370
  • Texas Valley Clinical Research LLC $18,472
  • Alicia Cabrera $13,196
  • Artemis Institute for Clinical Research LLC $12,920
  • Anesc Research $12,785
  • Neural Net Research LLC $12,753
  • Central State Research $11,984
  • Neurology Clinic PC $11,184
  • Neurology Associates of Tucson $10,106
  • Neuroscience Research Center LLC $9,984
  • Renstar Inc $9,979
  • Adult Medicine of Lake County $9,725
  • Qcare Site Services Inc $9,696
  • Mindful Medical Research $9,674
  • Compass Research East LLC $9,024
  • Neurologlocal Associates of Albany PC $8,600
  • Activmed Practices and Research LLC $8,406
  • Next Level Urgent Care LLC $8,114
  • Alexian Brothers Health System $7,460
  • Inspira Mental Health Management Inc $7,205
  • Banner Alzheimers Institute $6,122
  • Univ of Tx Health Sciences Center at San Antonio $5,850
  • Academic Alliance in Dermatology $5,773
  • Jem Headlands LLC $5,500
  • California PAcific Medical Ctr-Davies Campus Hosp, CA $5,374
  • Sfm Clinical Research LLC $4,959
  • Cognitive and Research Center of New Jersery LLC $4,923
  • Keystone Research LLC $4,875
  • Rehabilitation & Neurological Services, Ll $4,601
  • Minneapolis Clinic of Neurology $4,568
  • Medex Healthcare Research Inc $4,434
  • Dr Samuel Sanchez Psc $4,239
  • Instituto De Neurologia Dra Ivonne Frag Psc $3,794
  • Md Medical Research $3,100
  • Vancouver Clinic Inc Ps $2,606
  • Imic Inc $2,482
  • Overland PArk Surgical Specialties $1,950
  • Optimus U $1,843
  • Clinical Neuroscience Solutions DBA Cns Hlthcare $1,500
  • Masters of Clinical Research $1,289

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.