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A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

Terminated · Phase 3 · NCT05085366

Conditions: Cytomegalovirus Infection

At a glance

Research payments reported, 2025
$15.0M
U.S. investigators named
158
Sites paid
146
Planned or actual enrollment
7,454

About the trial

Sponsor
ModernaTX, Inc.
Tested
mRNA-1647 (biological), Placebo (biological)
Dates
Started 2021-10-26; completion 2025-11-04
Results posted
Not yet

The main purpose of this study is to evaluate the efficacy of mRNA 1647 vaccine in CMV-seronegative female participants and to evaluate the safety and reactogenicity of mRNA-1647 vaccine in all participants. The purpose of the Phase 3 extension substudy is to extend the observation period of the main study and to assess the longer-term immunogenicity, efficacy, and safety of the mRNA-1647 vaccine against primary CMV infection in healthy females who were CMV-seronegative at Baseline of the mRNA-1647-P301 main study (including participants who remain CMV-seronegative upon entry into the extension substudy and participants who seroconverted during the main study). The extension substudy will…

From ClinicalTrials.gov, last updated 2025-12-15. Full record, eligibility and contacts (opens in a new tab)

Industry funding

ModernaTX, Inc. reported $15.0M in research payments for this study in 2025 (3,001 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Velocity Clinical Research Inc $1.4M
  • Boeson Research LLC $814,343
  • Pharmaseek LLC $677,262
  • Bayview Research Group LLC $592,957
  • Rex Clinical Trials LLC $395,872
  • Seattle Crc LLC $382,517
  • J Lewis Research Inc $328,038
  • Sec Clinical Research LLC $302,799
  • Interspond LLC $298,780
  • Clinical Research Prime $296,908
  • Alliance for Multispecialty Research LLC $275,141
  • Dr Shelly David Senders MD $272,204
  • Clinical Research Institute Inc $242,560
  • The Research Foundation Suny $241,245
  • Indago Research and Health Center Inc $236,040
  • Lucas Research Inc $234,924
  • Elias Research Associates LLC $219,724
  • Skylight Health Research Inc $214,472
  • Primed Clinical Research LLC $209,955
  • M3 Wake Research Inc $202,345
  • Glri El PAso Research LLC $192,362
  • Lakeview Clinical Research $183,845
  • Cr Services Acquisition US LLC $182,936
  • Crossroads Clinical Research $182,177
  • Marwah Investments Corporation $173,550
  • Applied Research Center of Arkansas $169,245
  • Regents of the University of Minnesota $169,181
  • Tekton Research LLC $166,173
  • Dynamed Clinical Research LP $158,236
  • Ima Evaluations LLC $148,094
  • Epic Medical Research LLC $146,876
  • Tanner Clinic $134,988
  • Paradigm Clinical Rsrch Center Inc $131,921
  • Rochester Clinical Research Inc $127,155
  • Innovo Research Inc $126,098
  • Miami Clinical Research Lllp $126,067
  • Ideal Clinical Research $118,557
  • Noble Clinical Research LLC $117,579
  • Great Lakes Research Institute $114,219
  • Next Level Clinical Trials LLC $113,287
  • Johnson County Clin-Trials $112,915
  • Be Well Clinical Studies LLC $111,933
  • Carbon Health Technologies Inc $109,637
  • Lillestol Research LLC $108,362
  • Institute for Liver Health $104,970
  • Medical Clinical Research PArtners LLC $92,995
  • Dynamed Detroit LLC $91,585
  • Granger Medical Clinic $89,893
  • Long Beach Research Institute $89,652
  • Health Research of Hampton Road Inc $86,423
  • Baptist Health Center for Clinical Research $85,855
  • Lynn Health Science Institute $84,839
  • Hope Research Institute LLC $80,381
  • Community Research Management $76,853
  • University of Pittsburgh $73,644
  • Paradigm Clinical Rsrch Centers Inc $73,102
  • Cvs Health Clinical Trial Services LLC $69,368
  • Rainer Crc LLC $68,067
  • Chandler Clinical Trials LLC $68,007
  • Regents of the University of Colorado Denver $67,934
  • Edward Jenner Research Group Center LLC $66,926
  • Empire Clinical Research LLC $65,772
  • University of Wisconsin and Visual Sciences $65,258
  • Glri McAllen LLC $65,239
  • Dynamed Boston LLC $63,050
  • Elligo Health Research Inc $61,233
  • Clinical Trials Management Services LLC $61,134
  • Synergy Group Medical LLC $57,929
  • Central Research Associates $52,626
  • Northern California Research $51,986
  • Hattiesburg Clinic $51,890
  • Centennial Medical Group $51,314
  • Indago Research and Health $50,721
  • Activmed Practices Research LLC $48,514
  • The Board of Trustees of the Leland Stanford Junior University $48,032
  • University of California Davis Medical Center, CA $48,007
  • Institute for The Advancement $47,743
  • Del Sol Research Management LLC $47,666
  • Alsa Research LLC $47,564
  • Quality Clinical Research Inc $46,120
  • Centricity Fmhc LLC $42,857
  • Smart Cures Clinical Research $41,356
  • Cenexel Iresearch LLC $40,870
  • Helios Cr Inc $40,343
  • Clinical Trials of Texas Inc. $40,052
  • Universal Axon Clinical Research $40,004
  • Brcr Medical Center Inc $39,653
  • University of Texas Medical Branch Galveston, TX $39,472
  • Drug Studies America $38,980
  • Clinical Trials Management Ser $38,199
  • Emerson Clinical Research Institute $37,367
  • Wr Crcn LLC $37,166
  • Epic Medical Research $36,201
  • Paradigm Clinical Rsrch Center $36,125
  • Ascada Health PC $33,302
  • Preferred Research PArtners Inc $33,278
  • Albuquerque Clinical Trials $33,112
  • Alliance for Multispecialty $28,555
  • University of Michigan Health System, MI $28,208
  • Hometown Urgent Care and Rsch $27,943

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.