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Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma

Active, not recruiting · Phase 4 · NCT05097287

Conditions: Asthma

At a glance

Research payments reported, 2025
$3.3M
U.S. investigators named
64
Sites paid
58
Planned or actual enrollment
1,339

About the trial

Sponsor
Sanofi (with Regeneron Pharmaceuticals)
Tested
Dupilumab (drug), Placebo (drug)
Dates
Started 2021-12-16; completion 2029-06-08
Results posted
Not yet

This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function decline in adult patients with uncontrolled moderate to severe asthma. The estimated duration is 4±1 weeks of screening and run-in period, followed by a 3-year double blinded treatment period. There will be a post-treatment follow-up (FU) period up to 12 weeks.

From ClinicalTrials.gov, last updated 2026-04-16. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Genzyme Corporation reported $3.3M in research payments for this study in 2025 (595 payments).

Products named: Dupixent

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Clincare Llc Intracare Clinical $523,206
  • Elias Research Associates LLC $378,179
  • Beautiful Minds Medical Center Llc $326,187
  • Rex Tha Clinical Trials Llc $290,397
  • Prospective Research Innovations $152,161
  • Kern Allergy and Medical Research Inc $112,010
  • Metroplex Pulmonary and Sleep Center $100,700
  • Florida Center for Allergy Asthma Research $81,375
  • Respiratory Medicine Research Institute of Michigan Plc $73,224
  • Allergy and Clinical Immunology Associates, PC $69,344
  • Elligo Health Research Inc $63,578
  • Revival Research Institute, Inc $59,678
  • $57,421
  • Allergy and Asthma Specialists, Psc $54,727
  • Allianz Research Institute Inc $51,760
  • Adac Research PA $51,454
  • Nebraska Medical Research Inst Inc $47,922
  • Cliniverse Research Llc $47,413
  • Natl Allergy Asthma Research Llc $45,965
  • Andante Research Llc $40,335
  • Dynamed Clinical Research LP $40,136
  • Floridian Clinical Research Llc $39,970
  • University of Michigan Health System, MI $36,644
  • Javara Inc $35,412
  • Temple University of the Commonwealth System of Higher Education $31,927
  • Integrated Research of Inland Inc $30,655
  • Alpha Clinical Research Georgia Llc $29,589
  • Great Lakes Research Institute Llc $29,587
  • Stern Research PArtners Llc $29,455
  • Clinical Research Specialists Llc $29,000
  • Newportnativemd Inc $28,976
  • Emad Ghaly Focus Clinical Research Solutions Llc $23,501
  • Toledo Institute of Clinical Resear Inc $22,755
  • Kur Research Llc $21,055
  • Medical Advancement Centers of Arizona Llc $21,032
  • Chandler Clinical Trials Llc $20,871
  • Aeroallergy Research Laboratories of Savannah Inc $19,976
  • Rush University Medical Center, IL $18,034
  • Appalachian Clinical Research $17,353
  • Hmd Research Llc $16,366
  • Pulmonary Associates PA $16,098
  • University of Puerto Rico $16,013
  • Mercy General Hospital, CA $15,000
  • Urban Health Plan Inc $14,346
  • Family Allergy and Asthma $13,859
  • Rlb MD PC $12,016
  • Clinical Research of Gastonia $11,863
  • Clinical Trial Source LLC $10,083
  • Vitality Clinical Research Llc $8,780
  • Interspond LLC $6,957
  • St Lukes Hospital, PA $6,900
  • Vitality Clinical Research $6,600
  • Northshore University Healthsystem - Evanston Hospital, IL $4,475
  • Puerto Rico Consortium for Clinical Investigation $4,300
  • Tandem Clinical Research Llc $3,200
  • New Horizon Research Group Inc $2,099
  • Fundacion De Investigacion De Diego Inc Dba Fdi Clinical Research $1,325
  • Advanced Respiratory and Sleep Medicine, PLLC $1,299
  • Southeastern Research Center LLC $154

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.