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Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Completed · Phase 2 · NCT05103358

Conditions: Tumor, Tumor, Solid, Metastasis, Metastatic Cancer, Cancer, Cancer Metastatic, Tumors, Neoplasms, Neoplasm Metastasis, Solid Tumor, Advanced Solid Tumor, Advanced Cancer, Malignant Solid Tumor, Malignant Solid Neoplasm, Malignant Neoplasm, Malignant Tumor, TSC, TSC1, TSC2, Metastatic Solid Tumor, Metastatic Neoplasm

At a glance

Research payments reported, 2025
$2.9M
U.S. investigators named
52
Sites paid
48
Planned or actual enrollment
128

About the trial

Sponsor
Aadi Bioscience, Inc.
Tested
nab-sirolimus (drug)
Dates
Started 2022-03-10; completion 2024-12-23
Results posted
Yes

A Phase 2 multi-center open-label basket trial of nab-sirolimus for adult and adolescent patients with malignant solid tumors harboring pathogenic inactivating alterations in TSC1 or TSC2 genes

From ClinicalTrials.gov, last updated 2026-10-28. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Aadi Bioscience, Inc. reported $2.9M in research payments for this study in 2025 (203 payments).

Products named: Fyarro

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Ut MD Anderson Cancer Center $557,177
  • Rocky Mountain Cancer Centers (williams St) $381,338
  • Memorial Sloan Kettering Cancer Center $307,425
  • Karmanos Cancer Center, MI $187,306
  • The Nebraska Methodist Hospital, NE $108,430
  • Exigent Research LLC $107,224
  • Ronald Reagan UCLA Medical Center, CA $101,691
  • US Oncology Research LLC $75,767
  • Cleveland Clinic, OH $75,726
  • Sarcoma Oncology Research Center $71,174
  • Virginia Cancer Specialists $68,598
  • Thomas Jefferson University $66,057
  • Hope and Healing Cancer Services $64,930
  • Uw-Madison Deposit Account $62,034
  • University of Cincinnati Physicians Company LLC $54,589
  • Health Research Inc Roswell PArk Division $41,731
  • University of Washington Medical Ctr, WA $41,440
  • US Oncology Research $35,872
  • Sarah Cannon Research Institute LLC $35,372
  • Washington University School of Medicine $34,952
  • University of Cincinnati (uc) - Cancer Institute $32,024
  • The Board of Trustees of the Leland Stanford Junior University $31,455
  • South Texas Accelerated Research Therapeutics LLC $29,865
  • West Clinic Research Department $26,194
  • Virginia Cancer Specialists PC $26,110
  • Providence Medical Foundation $23,545
  • Dana-Farber Mass General Brigham Cancer Care Inc $22,946
  • City of Hope National Medical Center $19,286
  • Providence Medical Foundation - Santa Rosa Ca $19,019
  • Good Samaritan Hospital Trihealth $17,314
  • Toi Clinical Research LLC $15,575
  • Hope and Healing Cancer Services LLC $13,192
  • $12,411
  • Washington University Medical School $11,337
  • Qcca Network LLC $11,298
  • Hematology Oncology Associates of Fredericksburg $10,704
  • Iho Corporation $10,373
  • University of Cincinnati $9,829
  • Good Samaritan Hospital, OH $9,116
  • Morristown Medical Center, NJ $8,595
  • University of Southern California $8,085
  • Englewood Hospital and Medical Center, NJ $8,070
  • Board of Regents of the University of Oklahoma Health Sciences Center $7,365
  • Goshen Hospital Associationincdba $7,325
  • Oncology Consultants| P.a. $5,560
  • Hematology Oncology Associates of Fredricksburg Inc $4,357
  • American Oncology PArtners of Maryland PA $4,000
  • Prisma Health Greenville Memorial Hospital, SC $450

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.