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A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age

Completed · Phase 2, Phase 3 · NCT05127434

Conditions: Respiratory Syncytial Virus

At a glance

Research payments reported, 2025
$22.5M
U.S. investigators named
117
Sites paid
68
Planned or actual enrollment
36,814

About the trial

Sponsor
ModernaTX, Inc.
Tested
Placebo (drug), mRNA-1345 (drug)
Dates
Started 2021-11-17; completion 2025-07-28
Results posted
Yes

The main purpose of Part A of this study is to evaluate the safety and tolerability of mRNA-1345 vaccine and to demonstrate the efficacy of a single dose of mRNA-1345 vaccine in the prevention of a first episode of RSV-associated lower respiratory tract disease (RSV-LRTD) as compared with placebo from 14 days postinjection through 12 months. The main purpose of Part B of this study is to evaluate the safety, tolerability and immunogenicity of a booster dose (BD) of mRNA-1345 administered 24 months after the primary dose.

From ClinicalTrials.gov, last updated 2026-09-29. Full record, eligibility and contacts (opens in a new tab)

Industry funding

ModernaTX, Inc. reported $22.5M in research payments for this study in 2025 (1,547 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Qcare Site Services Inc $2.7M
  • Elligo Health Research Inc $1.8M
  • Dynamed Clinical Research LP $1.3M
  • Velocity Clinical Research Inc $1.2M
  • Qcare Site Services $1.1M
  • Pharmaseek LLC $984,197
  • Baptist Health Center for Clinical Research $862,141
  • Jacksonville Center for Clinical Research $692,512
  • Paradigm Clinical Rsrch Center Inc $557,108
  • Wr Pri LLC $532,369
  • Johnson County Clin-Trials $483,015
  • Rochester Clinical Research Inc $473,029
  • Wr Msra LLC $471,470
  • Marwah Investments Corporation $400,460
  • Tucson Neuroscience Research LLC $398,847
  • Wr Mount Vernon Clinical Research LLC $353,033
  • Hope Research Institute LLC $348,067
  • National Institute of Clinical Research $343,778
  • West Houston Clinical Research $332,529
  • Aim Trials LLC $329,222
  • Texas Center for Drug Development $312,151
  • Dynamed Detroit LLC $293,862
  • Drug Trials America Inc $293,514
  • Helios Cr Inc $273,124
  • Clinical Site PArtners $272,321
  • B&b Medical Inc $265,300
  • Javara Inc $253,580
  • Trial Management Associates LLC $234,733
  • Clinical Site PArtners LLC $215,152
  • Delricht LLC $203,652
  • Wr Mccr LLC $196,113
  • Dynamed Chicago LLC $191,629
  • Brcr Medical Center Inc $181,483
  • Drug Studies America $179,887
  • Cbh Health LLC $171,285
  • Seattle Crc LLC $168,000
  • Summit Headlands LLC $167,343
  • Achieve Clinical Research LLC $164,875
  • Rainer Crc LLC DBA Rainer Clin $163,824
  • Sandhill Research LLC $163,676
  • Rainer Crc LLC $162,176
  • Dynamed Philadelphia LLC $146,616
  • David Fitz-Patrick MD. Inc $146,036
  • Clinical Research Institute Inc $142,205
  • Science 37 Inc $134,838
  • Cra Headlands LLC $132,877
  • Fomat Medical Research Inc $129,572
  • Empirican Prn Inc $128,202
  • Montana Medical Research Inc $118,082
  • Panamerican Clinical Research $108,220
  • Tekton Research LLC $105,092
  • Cenexel Iresearch LLC $103,747
  • Caribbean Medical Research Center $102,500
  • Carolina Ins for Clin Research LLC $99,276
  • Lsb Research Group LLC $97,581
  • Clinical Trials of Texas Inc. $91,587
  • Clinical Research Consulting LLC $85,506
  • Cr Services Acquisition US LLC $82,080
  • Boeson Research LLC $71,971
  • Cra Headlands LLC DBA Clinical $66,353
  • Alliance for Multispecialty Research LLC $64,694
  • Black Hills Center for America $59,144
  • Lynn Health Science Institute $58,059
  • Great Lakes Research Institute $51,943
  • Community Research Management $39,991
  • Health Research of Hampton Road Inc $33,721
  • Recinto De Ciencias Medicas $23,672
  • Dm Clinical Research - Bellaire $2,754

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.