Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL
Completed · Phase 3 · NCT05164341
Conditions: Partial Lipodystrophy
At a glance
- Research payments reported, 2025
- $591,275
- U.S. investigators named
- 12
- Sites paid
- 12
- Planned or actual enrollment
- 69
About the trial
- Sponsor
- Chiesi Farmaceutici S.p.A.
- Tested
- metreleptin (drug), Placebo (drug)
- Dates
- Started 2021-12-17; completion 2026-10-06
- Results posted
- Not yet
This is a Phase III, double-blind, placebo-controlled, safety and efficacy study of daily SC metreleptin in subjects with Partial Lipodystrophy.
From ClinicalTrials.gov, last updated 2026-11-09. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Chiesi USA, Inc. reported $591,275 in research payments for this study in 2025 (351 payments).
Products named: Myalept
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Fernando Ovalle Endocrinology & Diabetes · Birmingham, AL
- Jose J. Lado-abeal, MD Endocrinology & Diabetes · Roseville, CA
- Rasha R. Youssef, M.D. Family Medicine · Boynton Beach, FL
- Doris Fadoju, MD Pediatric Endocrinology · Atlanta, GA
- Lindsay T. Fourman, MD Endocrinology & Diabetes · Boston, MA
- Elif Oral, MD Endocrinology & Diabetes · Ann Arbor, MI
- A J Vinaya Simha, MD Endocrinology & Diabetes · Rochester, MN
- Kathleen L. Wyne, M.D. Endocrinology & Diabetes · Columbus, OH
- Vaneeta Bamba, MD Pediatric Endocrinology · Philadelphia, PA
- Daniel E. Soffer, MD Internal Medicine · Media, PA
- Abhimanyu Garg, MD Endocrinology & Diabetes · Dallas, TX
- Bradley R. Javorsky, M.D. Endocrinology & Diabetes · Menomonee Falls, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- University of Michigan Health System, MI $173,858
- Children's Hospital of Philadelphia, PA $123,750
- Massachusetts General Hospital, MA $70,524
- University of Texas Southwestern Medical Center $54,193
- Children's Healthcare of Atlanta Inc $43,662
- Excel Medical Clinical Trials LLC $31,252
- The Ohio State University $28,924
- University of California Davis Medical Center, CA $27,166
- Mayo Clinic $13,528
- University of Alabama Hospital, AL $12,683
- The Medical College of Wisconsin Inc $8,664
- Hospital of Univ of Pennsylvania, PA $3,071
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.