A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
Active, not recruiting · Phase 4 · NCT05203510
Conditions: Pulmonary Arterial Hypertension
At a glance
- Research payments reported, 2025
- $2.1M
- U.S. investigators named
- 29
- Sites paid
- 27
- Planned or actual enrollment
- 52
About the trial
- Sponsor
- United Therapeutics (with Lung Biotechnology PBC)
- Tested
- Parenteral Treprostinil (drug), Oral Treprostinil (drug)
- Dates
- Started 2022-10-20; completion 2028-04-30
- Results posted
- Not yet
The primary objective of this study is to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in participants with pulmonary arterial hypertension (PAH).
From ClinicalTrials.gov, last updated 2025-12-09. Full record, eligibility and contacts (opens in a new tab)
Industry funding
United Therapeutics Corporation reported $2.1M in research payments for this study in 2025 (442 payments).
Products named: Remodulin
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Jonathan A. Moore Pulmonology · Phoenix, AZ
- Franz Rischard, DO Internal Medicine · Tucson, AZ
- Eyad Almasri, M.D. Pulmonology · Fresno, CA
- Roberto J. Bernardo, MD Critical Care Medicine · Stanford, CA
- Dael R. Geft, M.D. Heart Failure & Transplant Cardiology · Beverly Hills, CA
- Marc A. Simon, MD Heart Failure & Transplant Cardiology · San Francisco, CA
- Namita Sood, M.D. Pulmonology · Sacramento, CA
- Scott H. Visovatti, MD Cardiology · Lone Tree, CO
- Raj D. Parikh, M.D., M.P.H. Pulmonology · Hartford, CT
- Sashi Adigopula, M.D. Heart Failure & Transplant Cardiology · Fort Myers, FL
- Ricardo Restrepo-jaramillo, M.D. Pulmonology · Tampa, FL
- Chad Miller, MD Pulmonology · Austell, GA
- Ruben J. Mylvaganam, M.D. Pulmonology · Chicago, IL
- Clare C. Prohaska, M.D. Pulmonology · Indianapolis, IN
- Ahmed A. Tawakol, MD Cardiology · Boston, MA
- Aaron B. Waxman, M.D., PH.D Pulmonology · Boston, MA
- Gillian F. Grafton Gzym, D.O. Heart Failure & Transplant Cardiology · Detroit, MI
- Hubert J. Ford III, M.D. Pulmonology · Chapel Hill, NC
- Ronald Zolty, MD Cardiology · Omaha, NE
- Daniel J. Lachant, D.O. Pulmonology · Rochester, NY
- R J. White, MD Pulmonology · Rochester, NY
- Jean M. Elwing, MD Pulmonology · Cincinnati, OH
- John Kingrey, MD Pulmonology · Oklahoma City, OK
- Steven C. Stroud, M.D. Heart Failure & Transplant Cardiology · Tulsa, OK
- Ahmed Sadek, M.D. Cardiology · Philadelphia, PA
- Rahul G. Argula, MBBS Critical Care Medicine · Charleston, SC
- Jason L. Guichard, M.D., PH.D. Heart Failure & Transplant Cardiology · Greenville, SC
- Kelly Chin, M.D. Pulmonology · Dallas, TX
- Moises R. Cossio, D.O. Pulmonology · Roanoke, VA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Unehealth $194,299
- University of North Carolina $162,201
- Medical University of South Carolina $159,687
- Massachusetts General Hospital, MA $150,043
- Integris Baptist Medical Center, Inc, OK $143,153
- Strong Memorial Hospital, NY $134,755
- Temple University of the Commonwealth System of Higher Education $123,351
- Henry Ford Health Hospital, MI $117,467
- Community Hospital East, IN $78,158
- Prisma Health Greenville Memorial Hospital, SC $76,251
- Honor Health John C. Lincoln Medical Center, AZ $68,950
- Piedmont Healthcare, Inc. $63,632
- The Ohio State University $59,702
- Northwestern University $57,513
- The University of Texas Southwestern Medical Center $54,660
- Indiana University Health, IN $51,890
- The University of Arizona $45,718
- Carilion Medical Center, VA $41,488
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $40,585
- Oklahoma Heart Research and Education Foundation $39,580
- Prisma Health Richland Hospital, SC $38,880
- Cedars-Sinai Medical Center, CA $34,763
- The University of South Florida $32,228
- Brigham and Women's Hospital, MA $31,198
- University of California Davis Medical Center, CA $25,911
- University of Cincinnati $14,803
- Hartford Hospital, CT $11,355
- $3,610
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.