Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
Active, not recruiting · Phase 3 · NCT05215340
Conditions: Metastatic Non Small Cell Lung Cancer
At a glance
- Research payments reported, 2025
- $1.6M
- U.S. investigators named
- 29
- Sites paid
- 30
- Planned or actual enrollment
- 740
About the trial
- Sponsor
- Daiichi Sankyo (with AstraZeneca, Merck Sharp & Dohme LLC)
- Tested
- Datopotamab Deruxtecan (drug), Pembrolizumab (drug)
- Dates
- Started 2022-03-04; completion 2032-03-04
- Results posted
- Not yet
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab alone in participants with advanced or metastatic non-small cell lung cancer (NSCLC).
From ClinicalTrials.gov, last updated 2026-09-24. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Daiichi Sankyo Inc. reported $1.6M in research payments for this study in 2025 (535 payments).
Products named: Datroway
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Michael W. Meshad, MD Medical Oncology · Mobile, AL
- Iyad S. Hamarneh, MD Medical Oncology · Prescott, AZ
- Sujith R. Kalmadi, MD Hematology & Oncology · Chandler, AZ
- Eric M. Bank, M.D. Hematology & Oncology · Solvang, CA
- Michael L. Cheng, MD Medical Oncology · San Francisco, CA
- Aaron Lisberg, MD Hematology & Oncology · Santa Monica, CA
- Robert J. Hoyer, M.D. Hematology & Oncology · Colorado Springs, CO
- Venkat Pavan R. Kancharla, M.D Medical Oncology · Palm Bay, FL
- Michael J. Poiesz, M.D. Medical Oncology · Pensacola, FL
- David Hakimian, MD Hematology & Oncology · Niles, IL
- Benjamin H. Levy III, M.D. Gastroenterology · Chicago, IL
- Daniel B. Costa, M.D. Hematology & Oncology · Boston, MA
- Shail Maingi, MD Hematology & Oncology · South Weymouth, MA
- Jacob M. Sands, MD Hematology & Oncology · Burlington, MA
- Ralph V. Boccia, M.D. Hematology & Oncology · Bethesda, MD
- Konstantin H. Dragnev, MD Hematology & Oncology · Lebanon, NH
- Bruno S. Fang, MD Hematology & Oncology · East Brunswick, NJ
- Eli Kirshner, MD Hematology & Oncology · Westwood, NJ
- Iuliana Shapira, MD Hematology & Oncology · Little Silver, NJ
- Balazs Halmos, MD Hematology & Oncology · Cleveland, OH
- Sherri R. Cervantez, M.D. Medical Oncology · San Antonio, TX
- Habib M. Ghaddar, M.D. Hematology & Oncology · Weslaco, TX
- Donald A. Richards, MD Medical Oncology · Tyler, TX
- Caesar K. Tin-u, MD Medical Oncology · Sugar Land, TX
- Stephan D. Kendall, M.D. Medical Oncology · Salt Lake City, UT
- Vinni Juneja, MD Hematology & Oncology · Alexandria, VA
- Xingwei D. Sui, MD Medical Oncology · Lacey, WA
- Daniel Y. Wu, M.D., PH.D. Hematology & Oncology · Seattle, WA
- Jonathan Thompson, M.D. Hematology & Oncology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- US Oncology Inc $374,297
- Iho Corporation $162,162
- Uch-Memorial Health System, CO $156,071
- Dana-Farber Cancer Institute $135,824
- Titan Health PArtners Llc $116,256
- Texas Oncology, P.a. $91,726
- Johns Hopkins University $76,025
- Seattle Institute for Biomedical and Clinical Research $56,120
- Ironwood Physicians, PC $53,630
- Regional Cancer Care Associates $52,012
- Ronald Reagan UCLA Medical Center, CA $49,865
- Maryland Oncology Hematology, P.a. $35,099
- Providence Regional Cancer System $34,700
- Biomedical Research Alliance of New York LLC $32,617
- Southern Cancer Center, P.c. $31,878
- Urologic Health Associates $31,501
- University of Texas Health Science Center at San Antonio $24,864
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $22,472
- Mary Hitchcock Memorial Hospital, NH $21,245
- Medical College of Wisconsin $16,725
- American Oncology PArtners of Maryland PA $12,565
- Swedish Medical Center, WA $9,970
- The Valley Hospital $9,000
- Cancer Care Centers of Brevard Melbourne $2,868
- Santa Barbara Hematology Oncology Medical Group, Inc. $2,868
- Arizona Oncology Associates $2,868
- Illinois Cancer Specialists PC $2,868
- Woodlands Medical Specialists PA Admin Office $1,912
- Providence Health and Services Washington $1,750
- Oncology Hematology Consultants PA $625
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.