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Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor

Completed · Phase 2 · NCT05216250

Conditions: Upper Limb Essential Tremor (UL ET)

At a glance

Research payments reported, 2025
$379,027
U.S. investigators named
55
Sites paid
50
Planned or actual enrollment
174

About the trial

Sponsor
AbbVie
Tested
BOTOX (biological), Placebo for BOTOX (drug)
Dates
Started 2022-04-12; completion 2025-02-03
Results posted
Not yet

Upper limb essential tremor (UL ET) is a movement disorder characterized by postural and/or kinetic tremor. It can cause difficulty with everyday tasks such as writing, pouring, and eating, and patients also experience associated social embarrassment. This study will assess how safe and effective BOTOX is in treating UL ET. Adverse events and change in disease activity will be evaluated. BOTOX is an investigational drug being developed for the treatment of UL ET. Participants are randomly assigned to 1 of the 4 groups, called treatment arms. Each group receives different treatment. There is 1 in 2 chance that participants will be assigned to placebo. Around 174 participants, aged 18 to 80…

From ClinicalTrials.gov, last updated 2026-01-20. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $379,027 in research payments for this study in 2025 (141 payments).

Products named: Botox

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Loma Linda University Health $49,257
  • Texas Neurology PA $41,240
  • University of Texas Health Science $22,805
  • $21,591
  • St Josephs Hospital and Medical Center, AZ $20,199
  • Regents of University of Colorado $18,662
  • Ki Health PArtners LLC $18,056
  • Emory University Hospital, GA $16,442
  • Medical University South Carolina $15,702
  • Parkinson S Disease and Movement $15,299
  • University of North Carolina $12,299
  • Physicians Group Services PA $11,365
  • Tufts Medical Center, MA $10,440
  • University of Kansas Medical Center $10,094
  • Thomas Jefferson University $10,000
  • University of Pittsburgh Physicians $7,630
  • Ohsu Hospital and Clinics, OR $7,054
  • Kansas Institute of Research $6,879
  • The University of Arizona $6,682
  • Achieve Clinical Research LLC $6,355
  • Ichan School of Medicine at Mount Sinai $5,535
  • Dent Neurosciences Research $5,000
  • The University of Texas $3,800
  • Lahey Clinic Inc $3,700
  • Baylor College of Medicine $3,132
  • Charter Research LLC $2,553
  • Marshfield Clinic $1,700
  • Wake Forest University Student Health Services $1,553
  • Texas Movement Disorder $1,400
  • Parkinsons Disease and Movement $1,353
  • Wake Forest University $1,310
  • University of Texas Southwestern Medical Center $1,243
  • University of North Carolina at Chapel Hill $1,243
  • Dent Neurologic Institute $1,243
  • Marshfield Med Research and Education $1,243
  • Pmg Research Inc $1,243
  • University of Pittsburgh Physician $1,243
  • Medical University of South Carolina $1,243
  • Vivo Infusion Greenfield $1,083
  • Dayton Center for Neurological Disorders $1,083
  • Dayton Center for Neurological $1,000
  • Campus Health Services $932
  • University of Kansas Medical Center Research Institute Inc $932
  • Ut Health San Antonio $932
  • University of Colorado Denver School of Medicine $932
  • Lahey Medical Center Peabody $932
  • Kansas City Bone and Joint Clinic Overland PArk $812
  • Texas Movement Disorder Specialists $812
  • Integrated Neurology Services PLLC $812
  • The Orthopedic Foundation $812
  • Bcn Research LLC $167

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.