Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea
Completed · Phase 3 · NCT05412004
Conditions: Obstructive Sleep Apnea, Obesity
At a glance
- Research payments reported, 2025
- $122,826
- U.S. investigators named
- 9
- Sites paid
- 8
- Planned or actual enrollment
- 469
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Tirzepatide (drug), Placebo (drug)
- Dates
- Started 2022-06-21; completion 2024-03-29
- Results posted
- Yes
The purpose of this study is to evaluate the effect and safety of tirzepatide in participants with moderate to severe obstructive sleep apnea and obesity who are both unwilling or unable to use Positive Airway Pressure (PAP) therapy in GPI1 and those who are and plan to stay on PAP therapy in GPI2.
From ClinicalTrials.gov, last updated 2025-04-30. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $122,826 in research payments for this study in 2025 (17 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Stacey L. Layle, MD Family Medicine · San Diego, CA
- Mira Baron, MD, CPI Internal Medicine · West Palm Beach, FL
- Raj G. Karunakara, M.D. Pulmonology · Ocala, FL
- Kevin Prier Internal Medicine · Idaho Falls, ID
- James P. Maynard, M.D. Neurology · Fort Thomas, KY
- Michael J. Lillestol, M.D. Internal Medicine · Fargo, ND
- Paul Hartley, M.D. Internal Medicine · Uniontown, PA
- Bryce Palchick, M.D. Family Medicine · Pittsburgh, PA
- Aamr A. Herekar, M.D. Neurology · El Paso, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Preferred Primary Care Physicians Inc $70,396
- Anesc Research $17,041
- Cti Holdings Inc DBA Community Research Management Associates Inc $8,720
- Renstar Inc $7,091
- Lillestol Research LLC $6,024
- Artemis Institute for Clinical Research LLC $5,790
- Rocky Mountain Clinical Research LLC $4,954
- Palm Beach Research Center $2,810
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.