A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
Active, not recruiting · Phase 4 · NCT05433584
Conditions: Type 2 Diabetes
At a glance
- Research payments reported, 2025
- $1.8M
- U.S. investigators named
- 34
- Sites paid
- 28
- Planned or actual enrollment
- 780
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Tirzepatide (drug), Antihyperglycemic medication (drug)
- Dates
- Started 2022-08-01; completion 2027-11
- Results posted
- Not yet
This study aims to investigate the efficacy and safety of tirzepatide in participants with type 2 diabetes (T2D) compared to other existing treatment options when treatment is initiated early.
From ClinicalTrials.gov, last updated 2025-12-12. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $1.8M in research payments for this study in 2025 (48 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Jitendra Sharma, M.B.B.S Neurology · Birmingham, AL
- Song I. Yu, M.D. Family Medicine · Birmingham, AL
- Abid N. Chaudhry, DPM Podiatrists · Arleta, CA
- Stanley Hsia, M.D. Endocrinology & Diabetes · Los Angeles, CA
- Robert A. Jenders Internal Medicine · Torrance, CA
- Jeffrey London, MD Internal Medicine · West Hills, CA
- Anirudh R. Nandan Student in an Organized Health Care Education/Training Program · San Francisco, CA
- Jeffrey S. Overcash, MD Emergency Medicine · Chula Vista, CA
- Airani Sathananthan, MD Endocrinology & Diabetes · Pomona, CA
- Dennis Tsang, MD Hospitalist · Huntington Park, CA
- Jeffrey D. Wayne, MD Internal Medicine · Lincoln, CA
- Juan P. Loy, M.D. Internal Medicine · Margate, FL
- Rasha R. Youssef, M.D. Family Medicine · Boynton Beach, FL
- Angela D. Ritter, M.D. Family Medicine · Gainesville, GA
- Guillermo E. Umpierrez, M.D. Endocrinology & Diabetes · Atlanta, GA
- Anuj Bhargava, MD Endocrinology & Diabetes · West Des Moines, IA
- David E. Schultz II, M.D. Family Medicine · Evansville, IN
- Ehab Sorial, M.D. Internal Medicine · Fall River, MA
- Ralph J. Duda JR., M.D. Endocrinology & Diabetes · Springfield, MO
- Timothy R. Smith, M.D. Internal Medicine · Saint Peters, MO
- Bob Hutchins Internal Medicine · Jackson, MS
- Kathryn J. Lucas, MD Endocrinology & Diabetes · Morehead City, NC
- Trent L. Wei, MD Interventional Cardiology · Greensboro, NC
- Robert E. Dunn, MD Cardiac Electrophysiology · Cleveland, OH
- Brian M. Curtis, M.D. Internal Medicine · Corvallis, OR
- Patricia S. Hopson, DO Endocrinology & Diabetes · Corvallis, OR
- Donna M. Gavarone, DO Internal Medicine · Philadelphia, PA
- Paul Hartley, M.D. Internal Medicine · Uniontown, PA
- Gregorio A. Cortes-maisonet, MD General Practice · San Juan, PR
- Loida A. Gonzalez-rodriguez, MD Endocrinology & Diabetes · San Juan, PR
- Luis A. Pagan, MD General Practice · Dorado, PR
- Ronald K. Mayfield, M.D. Endocrinology & Diabetes · Spartanburg, SC
- Zackary D. Goff, M.D. Cardiology · Nashville, TN
- Julio Rosenstock, M.D. Endocrinology & Diabetes · Dallas, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Velocity Clinical Research Inc $278,891
- Sky Clinical Research Network Group $277,860
- Dorado Medical Complex Inc $192,516
- South Florida Wellness and Clinical Resear $143,342
- Gcm Medical Group Psc $136,922
- Corvallis Clinic PC $101,281
- San Fernando Valley Health Institute LLC $82,646
- Lucas Research Inc $63,484
- Studymetrix Research LLC $51,683
- Escuela De Medicina San Juan Bautista $47,608
- Iowa Diabetes and Endocrinology Rsrch Cntr $47,213
- Tribe Clinical Research LLC $42,449
- Center for Advanced Research & Education LLC $35,517
- Clinical Research Philadelphia LLC $33,882
- Clinvest Research LLC $32,393
- Clinical Trials Research Inc $32,362
- Emory University Hospital, GA $25,538
- Alliance for Multispecialty Research Lls $23,169
- Excel Medical Clinical Trials, LLC $21,436
- Western University of Health Sciences $20,487
- Qualmedica Research LLC $19,601
- Preferred Primary Care Physicians Inc $14,951
- Neccr Prima Care Research LLC $13,422
- Cahaba Research $12,463
- Cleveland Clinic, OH $942
- Andrew J Lewin Med DBA National Rsrch Institute $906
- Clinical Research of Philadelphia LLC $253
- Mountain View Clinical Research Inc $192
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.