Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer
Active, not recruiting · Phase 2 · NCT05456685
Conditions: High Grade Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
At a glance
- Research payments reported, 2025
- $1.0M
- U.S. investigators named
- 25
- Sites paid
- 25
- Planned or actual enrollment
- 125
About the trial
- Sponsor
- AbbVie
- Tested
- Mirvetuximab soravtansine (drug), Carboplatin (drug)
- Dates
- Started 2022-09-28; completion 2026-11
- Results posted
- Not yet
IMGN853-0420 is a multicenter, open-label, phase 2 study of carboplatin plus mirvetuximab soravtansine followed by mirvetuximab soravtansine continuation in folate receptor-alpha positive, recurrent platinum sensitive, high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancer following 1 prior line of platinum-based chemotherapy.
From ClinicalTrials.gov, last updated 2025-10-28. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $1.0M in research payments for this study in 2025 (109 payments).
Products named: Elahere
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Setsuko Chambers, MD Gynecologic Oncology · Tucson, AZ
- John K. Chan, MD Gynecologic Oncology · San Francisco, CA
- Wesleigh F. Edwards, MD, PHD Hematology & Oncology · San Diego, CA
- Gottfried E. Konecny, MD Hematology & Oncology · Los Angeles, CA
- Monica E. Lee, M.D. Hematology & Oncology · Fullerton, CA
- Alberto Mendivil, M.D. Gynecologic Oncology · Newport Beach, CA
- Bradley R. Corr, MD Gynecologic Oncology · Aurora, CO
- Alessandro Santin, MD OB-GYN (Obstetrics & Gynecology) · New Haven, CT
- Robert W. Holloway, MD Gynecologic Oncology · Orlando, FL
- Beverly J. Long, M.D. Gynecologic Oncology · Sarasota, FL
- Tiffany Lai Gynecologic Oncology · Honolulu, HI
- Patricia S. Braly, MD Gynecologic Oncology · Covington, LA
- Ursula A. Matulonis, MD Medical Oncology · Boston, MA
- Koji Matsuo, MD Student in an Organized Health Care Education/Training Program · Baltimore, MD
- Colleen C. Mccormick, M.D. OB-GYN (Obstetrics & Gynecology) · Baltimore, MD
- Ira S. Winer, MD Gynecologic Oncology · Royal Oak, MI
- Angeles A. Secord, MD Gynecologic Oncology · Durham, NC
- Linda Van Le, MD Gynecologic Oncology · Chapel Hill, NC
- Sharyn N. Lewin, M.D. Gynecologic Oncology · Teaneck, NJ
- Carolyn Y. Muller, MD Gynecologic Oncology · Albuquerque, NM
- Peter C. Lim, M.D. Specialist · Reno, NV
- Jason D. Wright, M.D. Gynecologic Oncology · New York, NY
- Lauren E. Dockery, M.D. Gynecologic Oncology · Oklahoma City, OK
- Cara A. Mathews, MD OB-GYN (Obstetrics & Gynecology) · Providence, RI
- Susan C. Modesitt, M.D. Gynecologic Oncology · Charlottesville, VA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Ronald Reagan UCLA Medical Center, CA $253,346
- Hoag Memorial Hospital Presbyterian $140,576
- Duke University $111,720
- Yale University $79,597
- Providence Medical Foundation $74,285
- Scripps Mercy Hospital, CA $44,747
- University of Southern California $42,840
- Adventhealth Orlando, FL $42,500
- Women's Cancer Care $38,200
- New Mexico Cancer Research Alliance $32,111
- California PAcific Medical Center- Van Ness Campus, CA $31,280
- Massachusetts General Hospital $29,462
- Peter C Lim MD LTD $25,894
- Women S Cancer Care $16,572
- Women & Infants Hospital of Rhode Island, RI $15,069
- Ov-UCLA Education & Research Institute $12,000
- Trustees of Columbia Uni $9,113
- Karmanos Cancer Center, MI $7,651
- The University of Arizona $6,537
- Holy Name Medical Center Inc $6,384
- Sarasota Memorial Hospital, FL $4,500
- Univ of Oklahoma Health Sciences Ce $2,350
- The Regents of the Uni of Colorado $1,920
- Univof N Carolina at Chapel Hill $1,280
- Emory University Hospital, GA $440
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.