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Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

Recruiting · Phase 2, Phase 3 · NCT05485961

Conditions: End Stage Kidney Disease

At a glance

Research payments reported, 2025
$42.4M
U.S. investigators named
183
Sites paid
99
Planned or actual enrollment
3,110

About the trial

Sponsor
CSL Behring
Tested
CSL300 (drug), Placebo (drug)
Dates
Started 2024-04-27; completion 2029-05-22
Results posted
Not yet

This is a two-part, phase 2b and phase 3 combined prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1: Phase 2b is a dose-finding study for CSL300 vs placebo. Part 2: Phase 3 aims to assess the efficacy of CSL300 vs placebo on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.

From ClinicalTrials.gov, last updated 2026-09-21. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Csl Behring reported $42.4M in research payments for this study in 2025 (5,000 payments).

Products named: Hizentra

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Duke University $10.9M
  • Total Renal Research Inc. $9.4M
  • Frenova, LLC $8.7M
  • National Institute of Clinical Research $2.4M
  • North America Research Institute $1.2M
  • Elixia Pines LLC $857,557
  • South Florida Research Organization LLC $657,840
  • American Clinical Trials LLC $548,029
  • Southern California Medical Research Center $527,023
  • Total Research Group, LLC $491,437
  • Usrc Kidney Research $392,845
  • Davita Clinical Research Nevada $385,872
  • Clinical Research Consultants LLC $341,510
  • Socal Research Associates LLC $316,782
  • Amicis Research Center $305,779
  • Family First Medical Research Center $264,989
  • Cleveland Clinic, OH $262,600
  • Elixia Mkc $255,249
  • Dialysis Clinic, Inc $247,593
  • Elegant Research Amd Development $239,520
  • Cn Clinical Research LLC $231,061
  • Coastal Medical Research LLC $222,889
  • Jpj Research $194,185
  • Renal Consultants Medical Group $192,974
  • Healthlinktmg LLC $191,038
  • Cussimanio Research Group LLC $182,343
  • North Carolina Nephrology $166,226
  • $156,806
  • St. Clair Nephrology Research, LLC $151,851
  • Iconic Clinical Research Inc $122,665
  • Kansas Nephrology Research Institute $118,652
  • Somnos Clinical Research $117,041
  • Nova Clinical Research, Llc. $113,724
  • Clinical Research Strategies, Inc. $107,164
  • Western Nephrology & Metabolic Bone Disease, PC $106,476
  • Peninsula Kidney Associates $97,356
  • Denver Nephrologists PC $81,990
  • Rhode Island Hospital, RI $78,020
  • Elixia Central Florida LLC $77,109
  • Clinical Site PArtners, LLC $71,586
  • New York University School of Medicine $63,784
  • Apex Research of Riverside $60,349
  • South Valley Nephrology Medical Research, Inc $58,716
  • Hypertension and Nephrology Association $55,002
  • Renal Research of Montgomery County $49,042
  • Floridian Clinical Research, LLC $46,538
  • The Feinstein Institute for Medical Research $41,352
  • Nephrology Associates of Northern Virginia $39,876
  • Horizon Research Group, LLC $39,335
  • Nani Research $36,061
  • Central Coast Nephrology Medical Corp $35,845
  • Medrasa Clinical Research $33,294
  • Biomedical Research and Education Foundation of Southern Arizona $29,147
  • Cedars-Sinai Medical Center, CA $26,109
  • Massachusetts General Hospital, MA $25,199
  • Investigadores Del Este LLC $24,576
  • Albany Research Institute, Inc. $22,802
  • Aqua Research Institute LLC $22,258
  • Minnesota Veterans Medical Research & Education Foundation $22,109
  • Md Trials, LLC $20,582
  • Panoramic Science LLC $19,065
  • Tufts Medical Center, MA $18,608
  • National Clinical Trials $17,741
  • Bronx Veterans Medical Research Foundation, Inc. $17,593
  • Advanced Medical Research Group $14,554
  • Mcguire Research Institute $14,437
  • Gulf Coast Clinical Research LLC $13,424
  • Laguna Clinical Research Associates, LLC $13,367
  • Dallas VA Research Corporation $11,615
  • Kidney & Hypertension Center $5,650
  • California Institute of Renal Research $5,115
  • Georgia Nephrology $4,903
  • Royal Research Corp $4,469
  • Arizona Kidney Disease & Hypertension Centers (akdhc) $4,000
  • The Medical Research Group, Inc. $3,872
  • Nephrology Consultants, LLC $3,469
  • Vanderbilt University Medical Center, TN $3,463
  • Nephrology and Hypertension Associates Ltd $3,452
  • Suny Downstate Medical Center Brooklyn $2,485
  • Midwest Veterans Biomedical Research Foundation $2,392
  • US Renal Care Inc. $2,230
  • Infigo Clinical Research LLC $2,213
  • VA Memphis Health Care $2,192
  • Albert Einstein College of Medicine $2,169
  • Columbia Nephrology $2,127
  • Imd Clinical Trials Inc $2,000
  • Premier Clinical Research $1,954
  • Aviva Health Services $1,937
  • University of Louisville Jewish Hospital $1,937
  • University of Chicago Medical Center $1,937
  • Renal Disease Research Institute $1,826
  • Sierra Nevada Specialty Care $1,465
  • Centro De Cuidado Renal, LLC $1,200
  • University of Cincinnati $1,200
  • Center for Advanced Kidney Research, PLC $971
  • Durham Nephrology Associates, PA $758
  • Metrolina Nephrology Associates, PA $534
  • East Carolina University $345
  • Miami Kidney Group $33
  • Genesis Clinical Research $17

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.