Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
Active, not recruiting · Phase 3 · NCT05555732
Conditions: Metastatic Non Small Cell Lung Cancer
At a glance
- Research payments reported, 2025
- $3.1M
- U.S. investigators named
- 29
- Sites paid
- 32
- Planned or actual enrollment
- 1,170
About the trial
- Sponsor
- Daiichi Sankyo (with AstraZeneca, Merck Sharp & Dohme LLC)
- Tested
- Datopotamab Deruxtecan (drug), Pembrolizumab (drug), Pemetrexed (drug), Carboplatin (drug), Cisplatin (drug)
- Dates
- Started 2023-01-11; completion 2031-05-11
- Results posted
- Not yet
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).
From ClinicalTrials.gov, last updated 2026-06-23. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Daiichi Sankyo Inc. reported $3.1M in research payments for this study in 2025 (1,043 payments).
Products named: Datroway
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Michael W. Meshad, MD Medical Oncology · Mobile, AL
- Iyad S. Hamarneh, MD Medical Oncology · Prescott, AZ
- Sujith R. Kalmadi, MD Hematology & Oncology · Chandler, AZ
- Eric M. Bank, M.D. Hematology & Oncology · Solvang, CA
- Brian S. Choi, M.D. Specialist · Riverside, CA
- Yaser Homsi, M.D. Hematology & Oncology · Huntington Beach, CA
- Aaron Lisberg, MD Hematology & Oncology · Santa Monica, CA
- Robert J. Hoyer, M.D. Hematology & Oncology · Colorado Springs, CO
- Ayed O. Ayed, M.D. Hematology & Oncology · Jacksonville, FL
- Adewale A. Fawole, M.D. Medical Oncology · The Villages, FL
- Amir Harandi, M.D. Medical Oncology · Bradenton, FL
- Venkat Pavan R. Kancharla, M.D Medical Oncology · Palm Bay, FL
- Michael J. Poiesz, M.D. Medical Oncology · Pensacola, FL
- Jennifer W. Carlisle, M.D. Hematology & Oncology · Atlanta, GA
- David Hakimian, MD Hematology & Oncology · Niles, IL
- Daniel B. Costa, M.D. Hematology & Oncology · Boston, MA
- Jacob M. Sands, MD Hematology & Oncology · Burlington, MA
- Ralph V. Boccia, M.D. Hematology & Oncology · Bethesda, MD
- Andrew S. Mener, M.D. Hematology & Oncology · Columbia, MD
- Bruno S. Fang, MD Hematology & Oncology · East Brunswick, NJ
- Iuliana Shapira, MD Hematology & Oncology · Little Silver, NJ
- Richard M. Zuniga, MD Hematology & Oncology · Babylon, NY
- Sherri R. Cervantez, M.D. Medical Oncology · San Antonio, TX
- Habib M. Ghaddar, M.D. Hematology & Oncology · Weslaco, TX
- Donald A. Richards, MD Medical Oncology · Tyler, TX
- Caesar K. Tin-u, MD Medical Oncology · Sugar Land, TX
- Stephan D. Kendall, M.D. Medical Oncology · Salt Lake City, UT
- Xingwei D. Sui, MD Medical Oncology · Lacey, WA
- Daniel Y. Wu, M.D., PH.D. Hematology & Oncology · Seattle, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- US Oncology Inc $572,717
- Providence Health and Services Washington $360,001
- Dana-Farber Cancer Institute $343,986
- Titan Health PArtners Llc $304,145
- Ronald Reagan UCLA Medical Center, CA $170,631
- Uch-Memorial Health System, CO $163,000
- University of Texas Health Science Center at San Antonio $149,819
- Ascension St Vincent's Riverside, FL $119,756
- Illinois Cancer Specialists PC $116,053
- Urologic Health Associates $101,246
- Sarah Cannon Research Institute $97,974
- Ironwood Physicians, PC $72,435
- American Oncology PArtners of Maryland PA $70,530
- Seattle Institute for Biomedical and Clinical Research $69,010
- Arizona Oncology Associates $61,167
- Emory University Hospital, GA $53,620
- Regional Cancer Care Associates $50,481
- Texas Oncology, P.a. $48,470
- Iho Corporation $47,580
- Compassionate Cancer Care Medical Group-Fountain Valley $26,562
- Los Angeles Hematology Oncology Medical Group $24,070
- Southern Cancer Center, P.c. $22,473
- Oncology Hematology Consultants PA $20,314
- Maryland Oncology Hematology, P.a. $19,064
- Cancer Specialists Llc $13,175
- Compassionate Care Reasearch Group Inc $8,597
- Providence Regional Cancer System $7,668
- New York Cancer and Blood Specialists $6,968
- Hoag Hospital Newport Beach $5,710
- Santa Barbara Hematology Oncology Medical Group, Inc. $2,868
- Cancer Care Centers of Brevard Melbourne $2,868
- Woodlands Medical Specialists PA Admin Office $1,912
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.