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A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting · Phase 3 · NCT05556512

Conditions: Obesity, Overweight

At a glance

Research payments reported, 2025
$12.5M
U.S. investigators named
198
Sites paid
163
Planned or actual enrollment
15,374

About the trial

Sponsor
Eli Lilly and Company
Tested
Tirzepatide (drug), Placebo (drug)
Dates
Started 2022-10-11; completion 2027-10
Results posted
Not yet

This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

From ClinicalTrials.gov, last updated 2026-10-07. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $12.5M in research payments for this study in 2025 (369 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Elligo Health Research Inc $421,108
  • Sky Clinical Research Network Group $416,939
  • Soma Clinical Trials LLC $337,189
  • American Health Network of in LLC $336,830
  • Spectrum Clinical Research Inc $277,186
  • Northeast Research Institute $276,770
  • Biopharma Informatic Inc $263,079
  • Valley Institute of Research LLC $217,746
  • Cotton Oneil Msd of Stormont Vail Healthcare $214,933
  • North Georgia Clinical Research $209,706
  • Felicidad Medical Research LLC $207,673
  • Velocity Clinical Research Inc $205,162
  • Clinical Research of West Florida Inc $198,385
  • Davita Clinical Research $191,822
  • Tri State Medical Group Inc $189,361
  • Peace River Cardiovascular Center $186,675
  • Ima Evaluations LLC DBA Ima Clinical Research $185,307
  • Center for Advanced Research & Education LLC $182,818
  • Studymetrix Research LLC $168,619
  • Biopharma Informatic Inc Research Center $163,859
  • Northwest Houston Clinical Research PLLC $157,904
  • Excel Medical Clinical Trials, LLC $155,488
  • Nsc Research Inc $152,308
  • Desert Med Group DBA Desert Oasis Hlthcare $149,024
  • Klr Business Group Inc $135,195
  • Clincial Research of Central Florida $134,382
  • Clinvest Research LLC $132,697
  • St Vincent Hospital, WI $129,899
  • New York University $129,818
  • Hb Clinical Trials Inc $127,777
  • Vip Trials LLC $126,227
  • Dorado Medical Complex Inc $124,730
  • Calin Arimie MD $124,601
  • Orlando Family Physicians $123,091
  • Texas Institute of Cardiology PA $121,364
  • Encore Medical Research of Boynton Beach LLC $119,671
  • National Clinical Research Inc $119,578
  • Qualmedica Research LLC $118,086
  • Arcturus Healthcare PLC, Troy Internal $117,946
  • Eastside Research Associates LLC $116,891
  • Pima Heart $116,549
  • Regents of the University of Colorado $107,844
  • Rochester Clinical Research Inc $103,312
  • Lillestol Research LLC $100,575
  • North Hills Medical Research $96,427
  • Preferred Primary Care Physicians Inc $96,002
  • Neighborhood Healthcare $95,554
  • Southern Endocrinology Associates PA $95,271
  • Clinical Trials of Texas Inc $93,290
  • Prairie Education and Research Coop $90,661
  • Kalo Clinical Research LLC $90,483
  • Cleveland Clinic, OH $90,161
  • Optumcare Clinical Trials LLC $89,838
  • Nebraska Educational Biomedical $88,757
  • South Florida Wellness and Clinical Resear $88,246
  • Advanced Research Inc $86,644
  • Louisville Metabolic $86,003
  • Olive Branch Family Medical Center $85,667
  • Fomat Medical Research Inc $84,503
  • Puerto Rico Medical Research $84,204
  • Elite Clinical Studies LLC $80,776
  • Jpj Research Inc DBA Valiance Clinical Research $76,597
  • Healthcare Research Network II LLC $76,578
  • Iowa Diabetes and Endocrinology Rsrch Cntr $76,098
  • Capital Area Research LLC $71,394
  • Nluc PLLC $70,827
  • Gcm Medical Group Psc $70,682
  • Sivalingam Medical Corporation Inc $70,328
  • Millennium Clinical Trials LLC $66,631
  • Central Washington Health Services $66,520
  • Irst Business Specialty Finance $63,472
  • Chase Medical Research LLC $63,079
  • Billings Clinic Hospital, MT $62,422
  • Austin Gastroenterology $61,906
  • Cardiology Associates of Fairfield $61,560
  • HCP Clinical Research LLC $59,402
  • Artemis Headlands LLC $58,911
  • Brigham and Women's Hospital, MA $58,075
  • National Diabetes & Obesity $56,059
  • Palm Research Center Inc $54,871
  • Rancho Cucamonga Clinical Research $54,618
  • Texas Valley Clinical Research LLC $52,929
  • Consano Clinical Research LLC $52,108
  • Wr Clinsearch LLC $51,391
  • Centennial Medical Group $51,279
  • Providence St Mary $50,442
  • Albany Medical College $50,394
  • Manati Medical for Clinical Research $49,216
  • Cr Services Acquisition US LLC $49,210
  • John Muir Med Fndtn DBA John Muir Phys Network $47,131
  • Hope Clinical Research and Wellness LLC $46,227
  • Research and Cardiovascular $44,523
  • Healtheast Medical Research Institute $44,461
  • Cardiology Consultants of Philadelphia $44,327
  • Scripps Mercy Hospital, CA $43,991
  • Elite Clinical Trials Lllp $43,910
  • Rainier Clinical Research Center $43,510
  • Diabetes and Thyroid Center $43,404
  • Neccr Prima Care Research LLC $42,810
  • Thomas Jefferson University $42,688

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.