A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
Terminated · Phase 2 · NCT05592275
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
At a glance
- Research payments reported, 2025
- $140,435
- U.S. investigators named
- 13
- Sites paid
- 10
- Planned or actual enrollment
- 332
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- LY3540378 (drug), Placebo (drug)
- Dates
- Started 2023-02-03; completion 2025-01-22
- Results posted
- Yes
The main purpose of this study is to assess the efficacy and safety of LY3540378 in adults with worsening heart failure with preserved ejection fraction
From ClinicalTrials.gov, last updated 2026-02-05. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $140,435 in research payments for this study in 2025 (14 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Jitendra Sharma, M.B.B.S Neurology · Birmingham, AL
- David S. Funt, M.D. Cardiology · Boca Raton, FL
- Julio Tallet, MD Cardiology · Pembroke Pines, FL
- David R. Pimentel, M.D. Cardiology · Boston, MA
- Kirkwood Adams, MD Cardiology · Chapel Hill, NC
- Andrew N. Abboud Student in an Organized Health Care Education/Training Program · Cleveland, OH
- Agam Bansal, MD Internal Medicine · Cleveland, OH
- Vincent Chen, MD Cardiology · Cleveland, OH
- Aurangzeb Baber, M.D. Heart Failure & Transplant Cardiology · Allentown, PA
- Alvin A. Chandra, M.D. Cardiology · Dallas, TX
- Cesar Y. Guerrero, M.D. Cardiology · Dallas, TX
- Wissam I. Khalife, M.D. Heart Failure & Transplant Cardiology · Galveston, TX
- Faisal Wahid, M. D. Cardiology · Mckinney, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Cleveland Clinic, OH $42,028
- University of North Carolina at Chapel Hill $25,462
- Board of Regents of the Univ of Wisconsin Systm $23,413
- Boston Medical Center, MA $17,223
- Baylor Research Institute $9,120
- University of Texas Medical Branch Galveston, TX $6,590
- South Florida Research Solution $6,448
- Texas Institute of Cardiology PA $4,900
- Excel Medical Clinical Trials, LLC $4,801
- The University of Texas $450
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.