Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy
Terminated · Phase 3 · NCT05604170
Conditions: Tuberous Sclerosis Complex
At a glance
- Research payments reported, 2025
- $961,192
- U.S. investigators named
- 31
- Sites paid
- 34
- Planned or actual enrollment
- 117
About the trial
- Sponsor
- Marinus Pharmaceuticals
- Tested
- Ganaxolone (drug)
- Dates
- Started 2022-05-16; completion 2025-04-02
- Results posted
- Yes
This is a Phase 3, global, open-label extension (OLE) study of adjunctive GNX treatment in children and adults with TSC who previously participated in either Study 1042-TSC-3001 or Study 1042-TSC-2001
From ClinicalTrials.gov, last updated 2025-10-01. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Immedica Pharma US, Inc. reported $961,192 in research payments for this study in 2025 (207 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Debopam Samanta, MD Child Neurology · Little Rock, AR
- Sotiris G. Mitropanopoulos, MD Neurology · Phoenix, AZ
- Angus Wilfong, MD Child Neurology · Phoenix, AZ
- Donald J. Phillips, M.D. Neurology · Orange, CA
- Rajsekar R. Rajaraman, M.D. Child Neurology · Los Angeles, CA
- Shifteh Sattar, MD Child Neurology · San Diego, CA
- Susan Koh, MD Neurology · Aurora, CO
- Lily H. Tran, MD Child Neurology · New Haven, CT
- Fernando N. Galan, M.D. Child Neurology · Miami, FL
- Jurriaan M. Peters, MD Child Neurology · Boston, MA
- David S. Wolf, M.D., PH.D. Child Neurology · Baltimore, MD
- Aimee F. Luat, M.D. Child Neurology · Detroit, MI
- Elaine C. Wirrell, MD Neurology · Rochester, MN
- Chon Lee, M.D. Child Neurology · Winston Salem, NC
- Rani K. Singh, MD Neurology · Concord, NC
- Muhammad S. Zafar, M.D. Neurology · Durham, NC
- Aliza S. Alter, M.D. Child Neurology · Livingston, NJ
- Inna Hughes, MD, PHD Child Neurology · Rochester, NY
- Emily Walsh, M.D. Child Neurology · Rochester, NY
- Elia M. Pestana Knight, M.D. Child Neurology · Cleveland, OH
- David Ritter, M.D., PH.D. Child Neurology · Cincinnati, OH
- Sita Paudel, M.D. Neurology · Hershey, PA
- Katherine Taub, MD Child Neurology · Philadelphia, PA
- Sarah E. Weatherspoon, M.D. Neurology · Memphis, TN
- James Wheless, MD Child Neurology · Memphis, TN
- Charuta N. Joshi, MBBS, MD Pediatrics · Dallas, TX
- Karen C. Keough, MD Neurology · Austin, TX
- Mary Kay Koenig, M.D. Child Neurology · Houston, TX
- Matthew T. Sweney, M.D. Child Neurology · Salt Lake City, UT
- Russ P. Saneto Child Neurology · Seattle, WA
- Mohammed Ilyas, MD Child Neurology · Marshfield, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- University of Texas Health Science Center at Houston $89,886
- Nemours Childrens Hospital, Florida, FL $84,757
- Arkansas Childrens Hospital Research Institute $77,999
- University of California San Diego $72,895
- Ronald Reagan UCLA Medical Center, CA $57,312
- Children's Hospital Colorado, CO $56,461
- The University of North Carolina at Chapel Hill $47,873
- U of Utah Neuropsychiatric Institute $46,934
- Duke University $40,501
- Le Bonheur Childrens Hospital Foundation $40,022
- Atrium Health $38,815
- The Children's Mercy Hospital, MO $36,114
- Boston Children's Hospital, MA $29,417
- Childrens Healthcare of Atlanta Inc $28,725
- The Nemours Foundation $24,704
- Seattle Children's Hospital, WA $23,316
- Phoenix Children's Hospital, AZ $20,500
- Cleveland Clinic, OH $18,275
- Mayo Clinic $16,789
- Midatlantic Epilepsy & Sleep $14,528
- Strong Memorial Hospital, NY $13,276
- University of Utah $12,395
- Cincinnati Children's Hospital Medical Center, OH $10,938
- Pennsylvania State University $9,090
- University of Texas Southwestern Medical Center $8,821
- Central Michigan University $7,525
- Children's Hospital of Orange County, CA $7,020
- Seattle Children's Hospital $6,832
- University of Utah Hospital and Clinics, UT $6,631
- Pediatrix Management Services Inc $4,012
- Children's Hospital of Philadelphia, PA $3,608
- University of Texas Southwestern Medical Center 2693 $2,721
- Institute of Neurology and Neurosurgery at St Barnabas LLC $1,750
- University of Florida $750
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.