Alzheimer's Disease Neuroimaging Initiative 4
Enrolling by invitation · NCT05617014
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Dementia
At a glance
- Research payments reported, 2025
- $481,650
- U.S. investigators named
- 1
- Sites paid
- 1
- Planned or actual enrollment
- 1,500
About the trial
- Sponsor
- University of Southern California (with Northern California Institute of Research and Education, National Institute on Aging (NIA), Alzheimer's Therapeutic Research Institute)
- Tested
- Neuraceq (radiation), Amyvid (radiation), Tauvid (radiation), MK-6240 (radiation), NAV4694 (radiation), PI-2620 (radiation)
- Dates
- Started 2023-06-09; completion 2027-07-31
- Results posted
- Not yet
The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease across the full disease spectrum. Building on the success of ADNI1, ADNI-GO, ADNI2, and ADNI3, ADNI4 integrates clinical, cognitive, imaging, genetic, and fluid biomarker data to characterize disease progression and predict cognitive decline. ADNI4 includes both in-clinic and remote cohorts and a small complementary sub-cohort, Together Exploring Aging Minds (TEAM-ADNI), which evaluates community-based recruitment and longitudinal data collection approaches.
From ClinicalTrials.gov, last updated 2026-09-29. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Life Molecular Imaging Ltd reported $481,650 in research payments for this study in 2025 (1 payments).
Products named: Neuraceq
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.