Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adult Participants 18 Years of Age and Older
Completed · Phase 1, Phase 2 · NCT05624606
Conditions: Influenza Immunization
At a glance
- Research payments reported, 2025
- $291,444
- U.S. investigators named
- 12
- Sites paid
- 12
- Planned or actual enrollment
- 682
About the trial
- Sponsor
- Sanofi Pasteur, a Sanofi Company
- Tested
- Quadrivalent Influenza mRNA Vaccine MRT5410 (biological), Quadrivalent Recombinant Influenza vaccine RIV4 (biological), Quadrivalent Inactivated Influenza Standard Dose QIV-SD (biological), Quadrivalent Inactivated Influenza High Dose QIV-HD (biological)
- Dates
- Started 2022-11-28; completion 2024-03-28
- Results posted
- Not yet
The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of up to 3 dose levels of Quadrivalent Influenza mRNA Vaccine MRT5410 compared to an active control (QIV SD, QIV HD \[adults ≥ 65 years of age only\], or RIV4) in adults 18 years of age and older.
From ClinicalTrials.gov, last updated 2025-03-18. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Sanofi Pasteur Inc. reported $291,444 in research payments for this study in 2025 (21 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Donald M. Brandon, M.D. Internal Medicine · San Diego, CA
- Javier F. Chang, M.D. Family Medicine · Claremont, CA
- Barry Heller, M.D. Emergency Medicine · Long Beach, CA
- Albert A. Nassir, M.D OB-GYN (Obstetrics & Gynecology) · Los Angeles, CA
- Mira Baron, MD, CPI Internal Medicine · West Palm Beach, FL
- Jose F. Cardona, M.D. General Practice · Miami, FL
- Nelia E. Sanchez-crespo, M.D. Internal Medicine · Hollywood, FL
- Michael A. Rausch, M.D. Family Medicine · Augusta, KS
- Gustavo R. Albizu, M.D. General Practice · Morovis, PR
- Rica Santiago, M.D Internal Medicine · Mt Pleasant, SC
- Faith L. Holmes, M.D. Family Medicine · Austin, TX
- Paul K. Pickrell, MD Rheumatology · Austin, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- B B Medical,inc Dba PAlm Beach Research Center $67,608
- Research Centers of America $40,308
- Century Research Institute Inc $37,822
- Long Beach Clinical Trials Llc $29,997
- Wellness Clinical Research (wcr) $27,711
- California Research Foundation $27,667
- Coastal Carolina Research Center,incorporation $25,228
- Elligo Health Research Inc $21,396
- Indago Research Health Center $5,336
- Velocity Clinical Research,inc $4,250
- Tekton Research Fredericksburg Road $3,621
- Alliance for Multispecialty Research,llc $500
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.