Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5413 in Adult Participants18 Years of Age and Older
Completed · Phase 1, Phase 2 · NCT05650554
Conditions: Influenza Immunization
At a glance
- Research payments reported, 2025
- $408,422
- U.S. investigators named
- 15
- Sites paid
- 11
- Planned or actual enrollment
- 682
About the trial
- Sponsor
- Sanofi Pasteur, a Sanofi Company
- Tested
- Quadrivalent Influenza mRNA Vaccine MRT5413 (biological), Quadrivalent Recombinant Influenza Vaccine (biological), Quadrivalent Influenza Standard Dose Vaccine (biological), Quadrivalent Influenza High-Dose Vaccine (biological)
- Dates
- Started 2022-12-12; completion 2024-04-02
- Results posted
- Not yet
The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of up to 3 dose levels of Quadrivalent Influenza messenger ribonucleic acid (mRNA) Vaccine MRT5413 compared to an active control (QIVstandard-dose (SD), QIV high-dose (HD) \[adults ≥ 65 years of age only\], or quadrivalent recombinant influenza vaccine (RIV4)) in adults 18 years of age and older.
From ClinicalTrials.gov, last updated 2025-03-19. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Sanofi Pasteur Inc. reported $408,422 in research payments for this study in 2025 (23 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Barry Heller, M.D. Emergency Medicine · Long Beach, CA
- Mark T. Leibowitz, M.D. Internal Medicine · Long Beach, CA
- Samuel Penziner Hospitalist · Los Angeles, CA
- Jose F. Cardona, M.D. General Practice · Miami, FL
- Jorge T. Caso, MD Family Medicine · Miami, FL
- Margaret Chang, MD Family Medicine · Edgewater, FL
- Jose L. Diaz, MD Pulmonology · Leesburg, FL
- Mark A. Turner, MD Family Medicine · Meridian, ID
- Margaret E. Rhee, MD OB-GYN (Obstetrics & Gynecology) · Akron, OH
- Gustavo R. Albizu, M.D. General Practice · Morovis, PR
- David Fried, MD Internal Medicine · East Greenwich, RI
- Rica Santiago, M.D Internal Medicine · Mt Pleasant, SC
- Natasha E. Ballard, M.D. Family Medicine · Chattanooga, TN
- Parke J. Hedges OB-GYN (Obstetrics & Gynecology) · San Antonio, TX
- Faith L. Holmes, M.D. Family Medicine · Austin, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Velocity Clinical Research,inc $237,398
- Velocity Clinical Research $51,711
- Indago Research and Health Center Inc $50,862
- Flourish Research, San Antonio $25,369
- Suncoast Research Associates Llc $15,840
- Clinical Site PArtners Llc Csp Orlando $7,321
- Elligo Health Research Inc $7,000
- Coastal Carolina Research Center,incorporation $5,966
- Wellness Clinical Research (wcr) $3,988
- Long Beach Clinical Trials Llc $1,681
- Wr Clinsearch, Llc $1,285
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.