A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age
Terminated · Phase 1 · NCT05701800
Conditions: Herpes Zoster
At a glance
- Research payments reported, 2025
- $2.5M
- U.S. investigators named
- 20
- Sites paid
- 17
- Planned or actual enrollment
- 659
About the trial
- Sponsor
- ModernaTX, Inc.
- Tested
- mRNA-1468 (biological), Placebo (biological), Shingrix (biological)
- Dates
- Started 2023-01-23; completion 2025-12-31
- Results posted
- Not yet
The purpose of this first-in-human study is to evaluate the safety and immunogenicity of mRNA-1468.
From ClinicalTrials.gov, last updated 2026-08-05. Full record, eligibility and contacts (opens in a new tab)
Industry funding
ModernaTX, Inc. reported $2.5M in research payments for this study in 2025 (624 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- David Guzman, M.D. Internal Medicine · Los Angeles, CA
- Clint Flanagan, MD Family Medicine · Dacono, CO
- James L. Andersen, M.D. Addiction Medicine · Eagle Lake, FL
- Jose L. Diaz, MD Pulmonology · Leesburg, FL
- Mark J. Rosenthal, D.O. Family Medicine · Homestead, FL
- William E. Sanchez, M.D. Internal Medicine · Hialeah, FL
- Joseph G. Surber, DO Family Medicine · Columbus, GA
- Mary Brown, MD Internal Medicine · Rockford, IL
- Carlos A. Fierro, MD General Practice · Kansas City, KS
- Corey Hebert Pediatrics · Gretna, LA
- Rupal Trivedi, MD Family Medicine · Saint Louis, MO
- David J. Ensz, M.D. Family Medicine · South Sioux City, NE
- David S. Wheeler, MD Pulmonology · Philadelphia, PA
- Ruben J. Santiago-lugo, M.D. Internal Medicine · Bayamon, PR
- Natasha E. Ballard, M.D. Family Medicine · Chattanooga, TN
- Earl F. Martin, MD Family Medicine · Tomball, TX
- Murtaza Mussaji, DO Internal Medicine · Houston, TX
- Russell K. Perry, MD Allergy & Immunology · Beaumont, TX
- Paul K. Pickrell, MD Rheumatology · Austin, TX
- Sarah I. Smiley, D.O. Hospitalist · Austin, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Dynamed Clinical Research LP $435,126
- Research Works San Juan $373,702
- Dynamed Philadelphia LLC $268,727
- Johnson County Clintrials LLC $250,873
- Floridian Clinical Research LLC $212,077
- Velocity Clinical Research Inc $206,941
- Dynamed Chicago LLC $152,047
- Clinical Site PArtners Inc $140,207
- Research Works Inc $134,528
- Great Lakes Clinical Trials LLC $121,636
- Linq Research LLC $112,077
- Wr-Clinsearch LLC $46,994
- Sandhill Research LLC $15,698
- Research Works - San Juan $15,495
- Gadolin Research LLC $10,386
- Cr Services Acquisition US LLC $7,101
- Tekton Research LLC $6,170
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.