DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
Recruiting · Not applicable · NCT05701917
Conditions: Venous Thromboembolism, Deep Venous Thrombosis, Post-Thrombotic Syndrome
At a glance
- Research payments reported, 2025
- $429,165
- U.S. investigators named
- 33
- Sites paid
- 9
- Planned or actual enrollment
- 300
About the trial
- Sponsor
- Inari Medical
- Tested
- ClotTriever System (device), Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc. (drug)
- Dates
- Started 2023-01-06; completion 2028-07-31
- Results posted
- Not yet
This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.
From ClinicalTrials.gov, last updated 2026-11-03. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Stryker Corporation reported $429,165 in research payments for this study in 2025 (297 payments).
Products named: Flowtriever Catheter, S, Ct Thrombectomy System Kit
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Joshua Balderman, M.D. Vascular Surgery · Tucson, AZ
- Venkataramanan Gangadharan, MBBS Cardiology · Phoenix, AZ
- John S. Schor, M.D. Cardiothoracic Surgery · Cottonwood, AZ
- Anthony H. Chau, M.D. Vascular Surgery · Orange, CA
- Bhavraj Khalsa, M.D. Interventional Radiology · Orange, CA
- Jonathan D. Lindquist, M.D. Interventional Radiology · Aurora, CO
- David T. Stewart, MD Radiology · Denver, CO
- Constantinos A. Constantinou, MD Cardiothoracic Surgery · Vernon Rockville, CT
- Hamid R. Mojibian, MD Interventional Radiology · New Haven, CT
- Saher S. Sabri, M.D. Interventional Radiology · Washington, DC
- Jesse J. Klein, DO Interventional Cardiology · Largo, FL
- Justin S. Lee, M.D. Interventional Radiology · Sarasota, FL
- Rajesh Malik, M.D. Vascular Surgery · Naples, FL
- Nicholas R. Turman, MD Radiology · Tampa, FL
- Alexander H. Hou, MD Vascular Surgery · Edgewood, KY
- Peter T. Burke, MD Cardiology · Lansing, MI
- Scott S. Kaatz, DO Internal Medicine · Detroit, MI
- Nicolas J. Mouawad Vascular Surgery · West Branch, MI
- Ambarish P. Bhat, M.D. Interventional Radiology · Springfield, MO
- Khanjan H. Nagarsheth, MD Vascular Surgery · Saint Louis, MO
- Joseph S. Rossi, MD Interventional Cardiology · Sanford, NC
- John Rundback, M.D. Interventional Radiology · Teaneck, NJ
- Sonya S. Noor, M.D. Vascular Surgery · Buffalo, NY
- Edvard Skripochnik, MD Vascular Surgery · Bronx, NY
- Tucker J. Harrison, DO Interventional Cardiology · Tulsa, OK
- Robert W. Ford, MD Interventional Radiology · Philadelphia, PA
- Abdullah Shaikh, MD Interventional Radiology · Pittsburgh, PA
- Brian J. Brown, M.D. Interventional Cardiology · Spartanburg, SC
- Gerald R. Fortuna, MD Vascular Surgery · West Columbia, SC
- Mark D. Iafrati, MD Vascular Surgery · Nashville, TN
- Michael C. Siah Vascular Surgery · Dallas, TX
- Douglas A. Murrey JR., M.D. Interventional Radiology · Spokane, WA
- Aravinda Nanjundappa, MD Interventional Cardiology · Beckley, WV
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- $342,288
- Henry Ford Health $30,276
- University of Maryland Baltimore $19,400
- Baycare Health System Inc $15,250
- Mymichigan Medical Center Midland, MI $14,040
- Saint Francis Hospital, Inc, OK $3,000
- Henry Ford Health Hospital, MI $2,779
- Ahn Research Institute $1,134
- Mclaren Health Care Corporation $611
- Honorhealth Research Institute $388
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.