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A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Completed · Phase 3 · NCT05803421

Conditions: Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease

At a glance

Research payments reported, 2025
$7.8M
U.S. investigators named
198
Sites paid
177
Planned or actual enrollment
2,749

About the trial

Sponsor
Eli Lilly and Company
Tested
Orforglipron (drug), Insulin Glargine (drug)
Dates
Started 2023-04-03; completion 2026-03-16
Results posted
Not yet

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2 years may include up to 27 visits.

From ClinicalTrials.gov, last updated 2026-04-17. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $7.8M in research payments for this study in 2025 (388 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Encore Medical Research of Weston LLC $495,713
  • Sky Clinical Research Network Group $417,317
  • L&c Professional Medical $284,539
  • Mgcendo LLC $216,844
  • Puerto Rico Medical Research $197,959
  • Indago Research & Health Center Inc $195,717
  • Eastside Research Associates LLC $169,820
  • Alliance for Multispecialty Research Lls $168,938
  • Valley Clinical Trials Inc $157,048
  • Cotton Oneil Msd of Stormont Vail Healthcare $152,014
  • West Orange Endocrinology PA $146,363
  • Northeast Research Institute $135,257
  • Baycare Clinical Research LLC $131,904
  • Precision Research Center $121,878
  • Texas Valley Clinical Research LLC $118,144
  • Velocity Clinical Research Inc $112,857
  • Piedmont Medical Research Associates Inc $109,543
  • Clinical Research Institute of Arizona LLC $107,535
  • Spectrum Clinical Research Inc $104,003
  • American Health Network of in LLC $103,906
  • Clinical Research Philadelphia LLC $102,892
  • Lucas Research Inc $100,317
  • Valley Institute of Research LLC $99,584
  • Manati Medical for Clinical Research $95,618
  • Ark Clinical Research LLC $94,153
  • Central State Research $93,029
  • Excel Medical Clinical Trials, LLC $87,621
  • Elias Research Associates LLC $83,828
  • Qualmedica Research LLC $83,046
  • Biopharma Informatic Inc $79,442
  • Ima Evaluations LLC DBA Ima Clinical Research $78,857
  • Capital Area Research LLC $76,540
  • Southern Endocrinology Associates PA $76,360
  • Care Access Research LLC $74,526
  • Revival Research Institute LLC $71,964
  • Preferred Primary Care Physicians Inc $71,528
  • Conquest Research LLC $68,436
  • Burke Internal Medicine Inc, DBA Manassas Clinical Research Cent $67,434
  • Syed Research Consultants LLC $66,655
  • Pacific Clinical Studies Inc $65,203
  • Elite Clinical Trials Lllp $58,943
  • Clinical Site PArtners LLC $58,828
  • Las Vegas Medical Research LLC $57,285
  • Compass Research East LLC $54,585
  • Tri State Medical Group Inc $53,791
  • South Texas Clinical Research $53,560
  • Juno Research LLC $53,485
  • Neighborhood Healthcare $53,155
  • University of North Carolina at Chapel Hill $51,472
  • Clinical Research Professionals LLC $50,302
  • Clincial Research of Central Florida $46,980
  • Great Lakes Clinical Trials $46,723
  • Renstar Inc $46,688
  • University of Iowa Hospital & Clinics, IA $46,458
  • Albany Stratton VA Medical Center $45,877
  • Sherman Clinical Research LLC $45,212
  • Clinvest Headlands LLC $44,595
  • Soma Clinical Trials LLC $43,411
  • Biopharma Informatic Inc Research Center $40,812
  • Regents of the University of Colorado $39,236
  • Lillestol Research LLC $38,875
  • Palm Research Center Inc $38,690
  • Wellness Clinical Research LLC $38,053
  • Endocrine Ips PLLC $37,135
  • Northwest Research Center $37,085
  • Northwest Houston Clinical Research PLLC $37,049
  • Elligo Health Research Inc $36,925
  • Cr Services Acquisition US LLC $36,076
  • St Vincent Hospital, WI $35,226
  • Pharmquest Life Sciences LLC $34,562
  • Universal Research Group LLC $34,520
  • Arcturus Healthcare PLC, Troy Internal $34,046
  • Memorial Research Medical Clinic $33,708
  • Clinical Research Institute of Northern Nevada $33,582
  • Dorado Medical Complex Inc $32,919
  • Denver Research Institute $32,610
  • Vip Trials LLC $32,280
  • Kalo Clinical Research LLC $31,347
  • Consano Clinical Research LLC $31,072
  • Research and Cardiovascular $29,757
  • Clinical Investigation Specialists Inc $29,362
  • Elite Clinical Studies LLC $28,740
  • Thyroid, Endocrinology, and Diabetes, PA, $28,088
  • East Coast Institute for Research $28,013
  • Cmr of Greater New Haven LLC $27,666
  • Chrysalis Clinical Research LLC $27,422
  • Institute for Liver Health LLC $27,313
  • Nyc Research Inc $27,293
  • Clinical Trials of Texas Inc $26,914
  • Centricity Fmhc LLC DBA Centricity Research $26,505
  • Sociedad Espanola De Medicina De La Adolescencia $25,627
  • The Research Center of the Upstate $25,515
  • Louisville Metabolic $25,323
  • Gcm Medical Group Psc $24,697
  • Mid Hudson Medical Research PLLC $24,683
  • Deaconess Medical Center, WA $22,977
  • Clinical Research Atlanta $21,689
  • Mindful Medical Research $20,487
  • Research Foundation of State Univ of Ny $19,546
  • Wasatch Clinical Research $19,393

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.