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Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Completed · Phase 3 · NCT05814627

Conditions: Rheumatoid Arthritis

At a glance

Research payments reported, 2025
$1.7M
U.S. investigators named
78
Sites paid
75
Planned or actual enrollment
487

About the trial

Sponsor
AbbVie
Tested
Upadacitinib (drug), Adalimumab (drug), Upadacitinib Matching Placebo (drug), Adalimumab Matching Placebo (drug)
Dates
Started 2023-06-15; completion 2026-07-15
Results posted
Not yet

Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will assess how safe and effective upadacitinib is in treating RA when compared to adalimumab in adult participants with inadequate response or intolerance to one TNF-inhibitor who are on a stable dose of methotrexate (MTX). Adverse events and change in disease activity will be assessed. Upadacitinib is an approved drug for the treatment of RA. This study is double-blinded means that neither the participants nor the study doctors will know who will be given upadacitinib and who will be given adalimumab. Study doctors put the participants in 1 of the 2 groups…

From ClinicalTrials.gov, last updated 2026-08-14. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $1.7M in research payments for this study in 2025 (426 payments).

Products named: Rinvoq, Humira

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Millennium Research LLC $204,827
  • Dynamed Clinical Research LP $92,568
  • Corazon USA LLC $92,048
  • Tekton Research Inc $82,716
  • Rheumatology Center of San Diego $77,566
  • Arizona Arthritis And $73,744
  • Jps Health Network, TX $55,922
  • Trinity Universal Research Associat $55,482
  • Clinical Research of West Florida $54,723
  • Hernandez & Trujillo LLC $46,455
  • Rasf-Clinical Research Center Inc $44,302
  • Next Innovative Clinical Research $41,499
  • Arthritis and Rheumatism $37,475
  • Baycare Health System Inc $35,336
  • Arthritis and Rheumatology $34,864
  • Rheumatic Disease $33,415
  • Gnp Consultants LLC $31,671
  • Paramount Medical Research $26,823
  • Rao Research LLC $26,464
  • Joint and Muscle Research Institute $24,182
  • Gcm Medical Group Psc $23,278
  • Deerbrook Medical Associates $22,903
  • Norman B Gaylis MD PA $22,125
  • Clin Investigation Specialists Inc $21,811
  • Sweet Hope Research Specialty Inc $19,800
  • Sun Research Institute LLC $18,517
  • R & H Clinical Research $17,378
  • West Tennessee Research Institute $16,634
  • NYU Grossman School of Medicine $16,225
  • Clinvest Headlands LLC $15,663
  • Newport Huntington Medical Group $15,465
  • Logan Health Medical Center, MT $15,035
  • Roshan Kotha Purushothan & $14,695
  • Trabecular Medical Group LLC $13,559
  • University of South Florida $13,075
  • Regents of University of Colorado $12,747
  • Advanced Rheumatology PC $12,420
  • Mindful Medical Research $12,385
  • Qualmedica Research LLC $12,325
  • Arizona Arthritis & Rheumatology $11,549
  • Research Physicians Network LLC $11,070
  • Hmd Research LLC $10,970
  • West Texas Clinical Research $10,362
  • Dartmouth Hitchcock Health $8,905
  • Aa Mrc LLC $7,518
  • Trinity Health $7,500
  • Providence Medical Foundation $7,105
  • Willow Rheumatology and Wellness $6,910
  • Lundquist Institute for Biomedical $6,751
  • Ochsner Medical Center Acute, LA $6,716
  • Millennium Clinical Trials LLC $6,071
  • Advanced Rheumatology of Houston $6,037
  • Western Ky Rheumatology PLLC $5,933
  • Accurate Clinical Research Inc $5,561
  • Omega Research Debary LLC $5,450
  • Valerius Medical Group and Research $5,257
  • Texas Digestive Disease Cons PLLC $5,100
  • Atlanta Research Center for $4,894
  • Clinical Research Philadelphia LLC $4,750
  • Biopharma Informatic LLC $4,450
  • Physician Research $4,335
  • Sunvalley Arthritis Center $3,865
  • Health Group of America LLC $3,600
  • Vipul Joshi MD PA $3,250
  • Orthomidwest PLLC $2,700
  • Center for Rheumatology Rsrch LLC $1,100
  • Arthur Snyder Arthritis And $615
  • St PAul Rheumatology PA $615
  • Rheumatology Associates $615
  • International Medical Research LLC $615
  • Wcg Clinical Inc $293
  • Trinity Universal Research Associates Inc $269
  • Valerius Medical Group and Research Center $177
  • Arthritis Rheumatic & Back Disease Associates $135
  • Millennium Research $135

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.